Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 1958066..1958642 Replicon chromosome
Accession NZ_CP109753
Organism Enterobacter roggenkampii strain 2017-45-131-01A

Toxin (Protein)


Gene name shpA Uniprot ID A0A656ULU9
Locus tag OI984_RS09665 Protein ID WP_025912099.1
Coordinates 1958355..1958642 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A7D6YIG8
Locus tag OI984_RS09660 Protein ID WP_025912101.1
Coordinates 1958066..1958368 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI984_RS09635 (OI984_09635) 1954173..1954718 + 546 WP_008501313.1 YfaZ family outer membrane protein -
OI984_RS09640 (OI984_09640) 1954718..1955038 + 321 WP_008501314.1 hypothetical protein -
OI984_RS09645 (OI984_09645) 1955084..1956454 - 1371 WP_045353156.1 NAD-dependent succinate-semialdehyde dehydrogenase -
OI984_RS09650 (OI984_09650) 1956606..1957349 + 744 WP_045353155.1 AraC family transcriptional regulator -
OI984_RS09655 (OI984_09655) 1957397..1958035 + 639 WP_045353154.1 LysE family translocator -
OI984_RS09660 (OI984_09660) 1958066..1958368 - 303 WP_025912101.1 BrnA antitoxin family protein Antitoxin
OI984_RS09665 (OI984_09665) 1958355..1958642 - 288 WP_025912099.1 BrnT family toxin Toxin
OI984_RS09670 (OI984_09670) 1958811..1960082 + 1272 WP_045353153.1 DUF445 domain-containing protein -
OI984_RS09675 (OI984_09675) 1960079..1961155 - 1077 WP_032655052.1 DUF2955 domain-containing protein -
OI984_RS09680 (OI984_09680) 1961145..1962212 - 1068 WP_025912094.1 HlyD family secretion protein -
OI984_RS09685 (OI984_09685) 1962209..1962679 - 471 WP_021240623.1 MarR family transcriptional regulator -
OI984_RS09690 (OI984_09690) 1962825..1963290 - 466 Protein_1904 winged helix-turn-helix domain-containing protein -
OI984_RS09695 (OI984_09695) 1963283..1963399 - 117 Protein_1905 amino acid-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11235.68 Da        Isoelectric Point: 7.4007

>T262067 WP_025912099.1 NZ_CP109753:c1958642-1958355 [Enterobacter roggenkampii]
MPTEYEWDSNKAKSNLQKHGIRFEDAVMVFDDPYHLSVQDRYENGEFRWQTIGLVQGLLVILVAHTVRFESGGEIIRIIS
ARKADRKERSRYEHR

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11413.02 Da        Isoelectric Point: 10.0592

>AT262067 WP_025912101.1 NZ_CP109753:c1958368-1958066 [Enterobacter roggenkampii]
MSIVKHKRGSAPEVSARREAELKALAEKPEAEIDYSDIPATDDEQWSGAVRGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656ULU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7D6YIG8

References