Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1440470..1441090 Replicon chromosome
Accession NZ_CP109753
Organism Enterobacter roggenkampii strain 2017-45-131-01A

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag OI984_RS07085 Protein ID WP_008499287.1
Coordinates 1440872..1441090 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag OI984_RS07080 Protein ID WP_008499288.1
Coordinates 1440470..1440844 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI984_RS07070 (OI984_07070) 1435598..1436791 + 1194 WP_021241633.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
OI984_RS07075 (OI984_07075) 1436814..1439960 + 3147 WP_045352698.1 multidrug efflux RND transporter permease subunit AcrB -
OI984_RS07080 (OI984_07080) 1440470..1440844 + 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
OI984_RS07085 (OI984_07085) 1440872..1441090 + 219 WP_008499287.1 HHA domain-containing protein Toxin
OI984_RS07090 (OI984_07090) 1441297..1441848 + 552 WP_008499286.1 maltose O-acetyltransferase -
OI984_RS07095 (OI984_07095) 1441966..1442433 + 468 WP_008499285.1 YlaC family protein -
OI984_RS07100 (OI984_07100) 1442405..1443865 - 1461 WP_045352700.1 PLP-dependent aminotransferase family protein -
OI984_RS07105 (OI984_07105) 1443967..1444677 + 711 WP_045352701.1 GNAT family protein -
OI984_RS07110 (OI984_07110) 1444674..1444814 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
OI984_RS07115 (OI984_07115) 1444817..1445077 - 261 WP_006176933.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T262066 WP_008499287.1 NZ_CP109753:1440872-1441090 [Enterobacter roggenkampii]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT262066 WP_008499288.1 NZ_CP109753:1440470-1440844 [Enterobacter roggenkampii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References