Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 788358..789155 Replicon chromosome
Accession NZ_CP109753
Organism Enterobacter roggenkampii strain 2017-45-131-01A

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag OI984_RS04000 Protein ID WP_045352937.1
Coordinates 788358..788879 (-) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID W7PG43
Locus tag OI984_RS04005 Protein ID WP_008499829.1
Coordinates 788886..789155 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI984_RS03970 (OI984_03975) 783941..784630 + 690 WP_045352931.1 pyrimidine utilization protein B -
OI984_RS03975 (OI984_03980) 784642..785028 + 387 WP_008499822.1 pyrimidine utilization protein C -
OI984_RS03980 (OI984_03985) 785036..785836 + 801 WP_045352934.1 pyrimidine utilization protein D -
OI984_RS03985 (OI984_03990) 785846..786436 + 591 WP_025912982.1 malonic semialdehyde reductase -
OI984_RS03990 (OI984_03995) 786446..786940 + 495 WP_023292823.1 pyrimidine utilization flavin reductase protein F -
OI984_RS03995 (OI984_04000) 786962..788284 + 1323 WP_045352935.1 pyrimidine utilization transport protein G -
OI984_RS04000 (OI984_04005) 788358..788879 - 522 WP_045352937.1 GNAT family N-acetyltransferase Toxin
OI984_RS04005 (OI984_04010) 788886..789155 - 270 WP_008499829.1 DUF1778 domain-containing protein Antitoxin
OI984_RS04010 (OI984_04015) 789217..790134 - 918 WP_025912980.1 DMT family transporter -
OI984_RS04015 (OI984_04020) 790254..790424 - 171 WP_013097201.1 general stress protein -
OI984_RS04020 (OI984_04025) 790816..791412 + 597 WP_008499831.1 NAD(P)H:quinone oxidoreductase -
OI984_RS04025 (OI984_04030) 791433..791660 + 228 WP_008499832.1 YccJ family protein -
OI984_RS04030 (OI984_04035) 791756..792433 - 678 Protein_800 contractile injection system protein, VgrG/Pvc8 family -
OI984_RS04035 (OI984_04040) 792434..792808 - 375 WP_241771487.1 Imm52 family immunity protein -
OI984_RS04040 (OI984_04045) 793193..793531 - 339 WP_241771488.1 Tox-REase-5 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19628.37 Da        Isoelectric Point: 7.4313

>T262064 WP_045352937.1 NZ_CP109753:c788879-788358 [Enterobacter roggenkampii]
VDNLTIEMFSEGKDYDFRGFDCGEPSLNVFLTEHLVRQHNGRILRGYLLKDRDGPRVLGYYTLSGSCFEKAMLPSKTQQR
RIPYSNVPSVTLGRLAIHKDLQGLEWGTTLVTHAMRVAYLASQAVGVHGIFVDALNDQAKQFYLKQGFIPLTDENSHSLF
FPTKSIERLFEQA

Download         Length: 522 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10262.72 Da        Isoelectric Point: 5.8836

>AT262064 WP_008499829.1 NZ_CP109753:c789155-788886 [Enterobacter roggenkampii]
MPALKKQRIDLRLTDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWNAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W7PG43

References