Detailed information of TA system TA026206

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 765409..766044
• Replicon: chromosome
• Accession: NC_017047
• Organism: Rahnella aquatilis HX2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: H8NSH0
• Locus tag: Q7S_RS25810
• Protein ID: WP_013574084.1
• Coordinates: 765862..766044 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: H8NSG9
• Locus tag: Q7S_RS03540
• Protein ID: WP_013574083.1
• Coordinates: 765409..765840 (-)
• Length: 144 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Q7S_RS03515	760618..762072	-	1455	WP_013574078.1	efflux transporter outer membrane subunit	-
Q7S_RS03520	762096..762617	-	522	WP_013574079.1	transcriptional repressor MprA	-
Q7S_RS03525	762792..763130	-	339	WP_013574080.1	L-valine transporter subunit YgaH	-
Q7S_RS03530	763120..763881	-	762	WP_015689404.1	AzlC family ABC transporter permease	-
Q7S_RS03535	764056..765240	-	1185	WP_013574082.1	MFS transporter	-
Q7S_RS03540	765409..765840	-	432	WP_013574083.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
Q7S_RS25810	765862..766044	-	183	WP_013574084.1	type II toxin-antitoxin system HicA family toxin	Toxin
Q7S_RS03545	766161..767156	-	996	WP_013574085.1	glycine betaine/L-proline ABC transporter substrate-binding protein ProX	-
Q7S_RS03550	767181..768191	-	1011	WP_013574086.1	glycine betaine/L-proline ABC transporter substrate-binding protein ProX	-
Q7S_RS03555	768297..769496	-	1200	WP_013574087.1	glycine betaine/L-proline ABC transporter permease ProW	-
Q7S_RS03560	769493..770689	-	1197	WP_015689405.1	glycine betaine/L-proline ABC transporter ATP-binding protein ProV	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (11-137)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6646.89 Da
• Isoelectric Point: 11.1595

>T26206 WP_013574084.1 NC_017047:c766044-765862 [Rahnella aquatilis HX2]
MKSTELIKALLAAGCELKRHRGGSHQIWWSPVTNKTFPVPHPKNDLPVGTLKSIRKMAGI

Nucleotide

• Length: 183 bp

>T26206 NC_017047:c766044-765862 [Rahnella aquatilis HX2]
ATGAAATCAACGGAATTGATTAAAGCGCTGCTTGCAGCGGGTTGTGAACTCAAGCGTCACCGGGGAGGAAGTCATCAAAT
TTGGTGGTCACCTGTCACCAACAAAACCTTTCCCGTTCCCCACCCCAAAAATGATTTACCTGTGGGAACTCTCAAATCCA
TTAGAAAAATGGCAGGGATATGA

Antitoxin

Protein

• Length: 144 a.a.
• Molecular weight: 16317.52 Da
• Isoelectric Point: 4.4314

>AT26206 WP_013574083.1 NC_017047:c765840-765409 [Rahnella aquatilis HX2]
MFFSVGLETPKDDKTAYGMVVPAFTAFDYGCFSAADTREEIAPMVREAILMTVEDLIESERFVVDDIFDAGHLVYAANPE
YADFDTWFLIDIDLSEFEGKAHRINISLPDTLIKRIDNKVKNHPSYRDRSHFLAMAARKELLT

Nucleotide

• Length: 432 bp

>AT26206 NC_017047:c765840-765409 [Rahnella aquatilis HX2]
ATGTTCTTTTCAGTCGGTCTTGAAACACCAAAAGATGACAAAACCGCTTACGGTATGGTGGTACCTGCATTTACCGCGTT
TGATTACGGATGCTTCTCTGCAGCGGATACCCGTGAAGAAATCGCCCCTATGGTTCGCGAAGCCATCCTGATGACAGTAG
AAGATTTGATCGAAAGCGAACGCTTTGTTGTTGACGATATTTTTGATGCAGGCCATTTGGTGTATGCCGCTAATCCCGAA
TATGCCGACTTCGATACCTGGTTTTTGATTGATATTGATCTCTCGGAATTCGAAGGGAAAGCGCATCGAATCAATATTTC
GCTGCCTGACACCCTGATCAAACGCATTGATAATAAAGTTAAAAATCATCCGTCATATCGCGACCGCAGCCATTTTCTGG
CGATGGCCGCACGTAAAGAATTGCTGACCTGA

Structures

Toxin

• AlphaFold DB: H8NSH0

Antitoxin

• AlphaFold DB: H8NSG9