262050

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 1480159..1480747 Replicon chromosome
Accession NZ_CP109744
Organism Citrobacter portucalensis strain 2017-45-163

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag OI981_RS07085 Protein ID WP_060683076.1
Coordinates 1480430..1480747 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A5B0STC7
Locus tag OI981_RS07080 Protein ID WP_032942057.1
Coordinates 1480159..1480437 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI981_RS07070 (OI981_07070) 1477612..1479243 + 1632 WP_003826514.1 Na/Pi cotransporter family protein -
OI981_RS07075 (OI981_07075) 1479359..1480048 - 690 WP_060683075.1 dipeptidase PepE -
OI981_RS07080 (OI981_07080) 1480159..1480437 - 279 WP_032942057.1 putative addiction module antidote protein Antitoxin
OI981_RS07085 (OI981_07085) 1480430..1480747 - 318 WP_060683076.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OI981_RS07090 (OI981_07090) 1481011..1481562 - 552 WP_060683077.1 AAA family ATPase -
OI981_RS07095 (OI981_07095) 1481817..1481999 + 183 WP_225623038.1 hypothetical protein -
OI981_RS07100 (OI981_07100) 1482049..1482861 - 813 WP_060683079.1 shikimate 5-dehydrogenase -
OI981_RS07105 (OI981_07105) 1482863..1484086 - 1224 WP_060683080.1 L-sorbose 1-phosphate reductase -
OI981_RS07110 (OI981_07110) 1484155..1484979 - 825 WP_060683081.1 PTS system mannose/fructose/sorbose family transporter subunit IID -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-96)

Antitoxin

Uncharacterized protein HI1420

(3-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11959.93 Da        Isoelectric Point: 9.2299

>T262050 WP_060683076.1 NZ_CP109744:c1480747-1480430 [Citrobacter portucalensis]
IMEILQTMVFQRWEHNLRDRRAKTLIATRLFRLANGLAGDVKPVGEGVSEMRISYGPGYRIYFKQQGCRIIILLCGGDKS
SQANDITLAKMLARTLDSQEVFCHE

Download         Length: 318 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9872.45 Da        Isoelectric Point: 5.8233

>AT262050 WP_032942057.1 NZ_CP109744:c1480437-1480159 [Citrobacter portucalensis]
MNKLTHYDPATALVDDEEIAVFMADALETGDAAYIAKALGVVARAKGMANIAAETGLSREQLYRSFSEKGNPTLKTTLAV
MKVLGIELTLKK

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5B0STC7

References