Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3000371..3000933 Replicon chromosome
Accession NZ_CP109739
Organism Serratia nevei strain 2017-45-174

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag OI978_RS14465 Protein ID WP_047730131.1
Coordinates 3000577..3000933 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A8G2G5I1
Locus tag OI978_RS14460 Protein ID WP_004936539.1
Coordinates 3000371..3000580 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI978_RS14435 (OI978_14430) 2996519..2996845 + 327 WP_004936551.1 phage holin, lambda family -
OI978_RS14440 (OI978_14435) 2996835..2997236 + 402 WP_038881240.1 M15 family metallopeptidase -
OI978_RS14445 (OI978_14440) 2997233..2997613 + 381 WP_047730130.1 DUF2570 family protein -
OI978_RS14450 (OI978_14445) 2997594..2997767 + 174 WP_038881246.1 hypothetical protein -
OI978_RS14455 (OI978_14450) 2997983..3000262 + 2280 WP_038881248.1 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase -
OI978_RS14460 (OI978_14455) 3000371..3000580 + 210 WP_004936539.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
OI978_RS14465 (OI978_14460) 3000577..3000933 + 357 WP_047730131.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
OI978_RS14470 (OI978_14465) 3000945..3001883 - 939 WP_284593892.1 homocysteine S-methyltransferase -
OI978_RS14475 (OI978_14470) 3001873..3003282 - 1410 WP_134267997.1 S-methylmethionine permease -
OI978_RS14480 (OI978_14475) 3003460..3004299 + 840 WP_284598211.1 ChaN family lipoprotein -
OI978_RS14485 (OI978_14480) 3004402..3005196 + 795 WP_060442057.1 TonB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(20-114)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13161.95 Da        Isoelectric Point: 4.9139

>T262041 WP_047730131.1 NZ_CP109739:3000577-3000933 [Serratia nevei]
MIFLTAEDIAEFNAEIVPHGRQEGRKVEAAANRVLNAYHYENVTDVYRLAALYLIAISHGHIFLDGNKRTAFQSMALFLG
INGIALREDAELVEITVEAAQGRLNVEQAAEHLRLLTE

Download         Length: 357 bp

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7749.96 Da        Isoelectric Point: 10.1768

>AT262041 WP_004936539.1 NZ_CP109739:3000371-3000580 [Serratia nevei]
MTTISYTAARNNLAEVLLEAQKQPVEVTRRGHDEVYIISKADYEVLVKAKVKARIQAKHADTIKALANR

Download         Length: 210 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References