Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2919777..2920433 Replicon chromosome
Accession NZ_CP109739
Organism Serratia nevei strain 2017-45-174

Toxin (Protein)


Gene name vapC Uniprot ID A0A5C7DE55
Locus tag OI978_RS14085 Protein ID WP_047730091.1
Coordinates 2920044..2920433 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8G2LCA8
Locus tag OI978_RS14080 Protein ID WP_004941563.1
Coordinates 2919777..2920040 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI978_RS14065 (OI978_14060) 2916067..2916978 - 912 WP_284593742.1 lipid kinase YegS -
OI978_RS14070 (OI978_14065) 2917446..2918798 - 1353 WP_038873761.1 tRNA 5-hydroxyuridine modification protein YegQ -
OI978_RS14075 (OI978_14070) 2919100..2919438 - 339 WP_038873760.1 YegP family protein -
OI978_RS14080 (OI978_14075) 2919777..2920040 + 264 WP_004941563.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
OI978_RS14085 (OI978_14080) 2920044..2920433 + 390 WP_047730091.1 type II toxin-antitoxin system VapC family toxin Toxin
OI978_RS14090 (OI978_14085) 2920438..2921154 - 717 WP_047730092.1 two-component system response regulator BaeR -
OI978_RS14095 (OI978_14090) 2921164..2922537 - 1374 WP_047730093.1 two-component system sensor histidine kinase BaeS -
OI978_RS14100 (OI978_14095) 2922534..2923964 - 1431 WP_047730094.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14337.57 Da        Isoelectric Point: 7.8794

>T262040 WP_047730091.1 NZ_CP109739:2920044-2920433 [Serratia nevei]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELLYGVAKRRNKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RANMERKGKIMGALDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10062.31 Da        Isoelectric Point: 4.6702

>AT262040 WP_004941563.1 NZ_CP109739:2919777-2920040 [Serratia nevei]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C7DE55

Antitoxin

Source ID Structure

References