Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1333492..1334093 Replicon chromosome
Accession NZ_CP109739
Organism Serratia nevei strain 2017-45-174

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag OI978_RS06365 Protein ID WP_033636540.1
Coordinates 1333713..1334093 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0G3SPC0
Locus tag OI978_RS06360 Protein ID WP_038875999.1
Coordinates 1333492..1333713 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI978_RS06340 (OI978_06335) 1328641..1329618 + 978 WP_016929588.1 glyoxylate/hydroxypyruvate reductase GhrB -
OI978_RS06345 (OI978_06340) 1329620..1329772 - 153 WP_168166338.1 hypothetical protein -
OI978_RS06350 (OI978_06345) 1329968..1332031 + 2064 WP_284597311.1 alpha-amylase -
OI978_RS06355 (OI978_06350) 1332167..1333417 + 1251 WP_004933935.1 valine--pyruvate transaminase -
OI978_RS06360 (OI978_06355) 1333492..1333713 + 222 WP_038875999.1 ribbon-helix-helix domain-containing protein Antitoxin
OI978_RS06365 (OI978_06360) 1333713..1334093 + 381 WP_033636540.1 type II toxin-antitoxin system VapC family toxin Toxin
OI978_RS06370 (OI978_06365) 1334104..1335762 - 1659 WP_047729572.1 putative transporter -
OI978_RS06375 (OI978_06370) 1335930..1336358 - 429 WP_004933922.1 small heat shock chaperone IbpB -
OI978_RS06380 (OI978_06375) 1336459..1336872 - 414 WP_004933919.1 small heat shock chaperone IbpA -
OI978_RS06385 (OI978_06380) 1337182..1337529 + 348 WP_016929593.1 YceK/YidQ family lipoprotein -
OI978_RS06390 (OI978_06385) 1337560..1338840 - 1281 WP_047729573.1 DUF3748 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-102)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14185.53 Da        Isoelectric Point: 7.3170

>T262037 WP_033636540.1 NZ_CP109739:1333713-1334093 [Serratia nevei]
MVAQRALFDTNILIDYLNGIPQAKDVLTEYHINPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIIWATAQVGFRTLISRNPKDFGTDNGVLMPYRL

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8563.50 Da        Isoelectric Point: 4.4791

>AT262037 WP_038875999.1 NZ_CP109739:1333492-1333713 [Serratia nevei]
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLAENHVEDPSNAFGLWSGAMGDGVDYENRQREEWE

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3SPC0

References