Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 1292656..1293191 Replicon chromosome
Accession NZ_CP109739
Organism Serratia nevei strain 2017-45-174

Toxin (Protein)


Gene name relE Uniprot ID A0A854J4R0
Locus tag OI978_RS06185 Protein ID WP_038875945.1
Coordinates 1292656..1292931 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A5P6GNG1
Locus tag OI978_RS06190 Protein ID WP_038875948.1
Coordinates 1292931..1293191 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI978_RS06165 (OI978_06160) 1288475..1289467 - 993 WP_055311809.1 acyltransferase -
OI978_RS06170 (OI978_06165) 1289685..1290932 + 1248 WP_038875940.1 MFS transporter -
OI978_RS06175 (OI978_06170) 1290985..1291611 - 627 WP_284597279.1 LysE family translocator -
OI978_RS06180 (OI978_06175) 1291733..1292644 + 912 WP_284597282.1 LysR family transcriptional regulator -
OI978_RS06185 (OI978_06180) 1292656..1292931 - 276 WP_038875945.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OI978_RS06190 (OI978_06185) 1292931..1293191 - 261 WP_038875948.1 ribbon-helix-helix domain-containing protein Antitoxin
OI978_RS06195 (OI978_06190) 1293274..1295115 - 1842 WP_284597283.1 selenocysteine-specific translation elongation factor -
OI978_RS06200 (OI978_06195) 1295112..1296506 - 1395 WP_047729550.1 L-seryl-tRNA(Sec) selenium transferase -
OI978_RS06205 (OI978_06200) 1296575..1297180 - 606 WP_038875954.1 glutathione S-transferase -
OI978_RS06210 (OI978_06205) 1297221..1297871 - 651 WP_047729554.1 DcrB-related protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10548.34 Da        Isoelectric Point: 10.6099

>T262036 WP_038875945.1 NZ_CP109739:c1292931-1292656 [Serratia nevei]
MALKWTSKALSDLARLFEFLALANRTVAANSVKALVAAPKALLDNPRLGERLDEFLPQEVRRILVGRYEIRYQVQPATIY
VLRIWHTREER

Download         Length: 276 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9667.98 Da        Isoelectric Point: 4.5201

>AT262036 WP_038875948.1 NZ_CP109739:c1293191-1292931 [Serratia nevei]
MNTKVITAHVPLPLAEKVDEMAAKLERSRGWIVKQALAAWLEQEEERRRLTLAALADVEQQNVIDHESVEAWAASLDSDD
PLPVPR

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A854J4R0

Antitoxin

Source ID Structure
AlphaFold DB A0A5P6GNG1

References