Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1158251..1158723 Replicon chromosome
Accession NZ_CP109739
Organism Serratia nevei strain 2017-45-174

Toxin (Protein)


Gene name relE Uniprot ID A0A255N1I8
Locus tag OI978_RS05545 Protein ID WP_047729413.1
Coordinates 1158251..1158526 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag OI978_RS05550 Protein ID WP_033649649.1
Coordinates 1158526..1158723 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI978_RS05530 (OI978_05525) 1153294..1153671 - 378 WP_047729408.1 AprI/Inh family metalloprotease inhibitor -
OI978_RS05535 (OI978_05530) 1153727..1155190 - 1464 WP_038874135.1 serralysin family metalloprotease -
OI978_RS05540 (OI978_05535) 1155873..1158191 + 2319 WP_284597151.1 zinc/cadmium/mercury/lead-transporting ATPase -
OI978_RS05545 (OI978_05540) 1158251..1158526 - 276 WP_047729413.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
OI978_RS05550 (OI978_05545) 1158526..1158723 - 198 WP_033649649.1 hypothetical protein Antitoxin
OI978_RS05555 (OI978_05550) 1158785..1159030 - 246 WP_025304890.1 sulfurtransferase TusA -
OI978_RS05560 (OI978_05555) 1159251..1159910 + 660 WP_047729415.1 7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter -
OI978_RS05565 (OI978_05560) 1159962..1160396 + 435 WP_047729416.1 GNAT family N-acetyltransferase -
OI978_RS05570 (OI978_05565) 1160477..1161040 + 564 WP_047729417.1 DcrB family lipoprotein -
OI978_RS05575 (OI978_05570) 1161076..1162275 - 1200 WP_048232396.1 anaerobic glycerol-3-phosphate dehydrogenase subunit GlpC -
OI978_RS05580 (OI978_05575) 1162272..1163540 - 1269 WP_055313077.1 glycerol-3-phosphate dehydrogenase subunit GlpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10694.62 Da        Isoelectric Point: 11.2806

>T262035 WP_047729413.1 NZ_CP109739:c1158526-1158251 [Serratia nevei]
MLNIEWTRVARQDLGEIVGFIANDNPLAARKMKVLIMEAVIPAARHPRIFRRGRVDGTHEIPLHPHYLLVYQVLETHIRV
LRVLHTRRQYP

Download         Length: 276 bp

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7398.49 Da        Isoelectric Point: 4.4143

>AT262035 WP_033649649.1 NZ_CP109739:c1158723-1158526 [Serratia nevei]
MSILLLPTVAKMENEERTQGYERWFLERVQEAMDEPRPGIPHDDVMAEMDAVIAAAEARIKAKQA

Download         Length: 198 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A255N1I8

Antitoxin

Source ID Structure

References