Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 882554..883125 Replicon chromosome
Accession NZ_CP109739
Organism Serratia nevei strain 2017-45-174

Toxin (Protein)


Gene name relE Uniprot ID A0A0G3SNA4
Locus tag OI978_RS04250 Protein ID WP_038879053.1
Coordinates 882554..882829 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A086G7I5
Locus tag OI978_RS04255 Protein ID WP_013811307.1
Coordinates 882838..883125 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI978_RS04230 (OI978_04225) 877987..878511 - 525 WP_047729213.1 NAD(P)H-dependent oxidoreductase -
OI978_RS04235 (OI978_04230) 878618..879532 + 915 WP_048232521.1 LysR family transcriptional regulator -
OI978_RS04240 (OI978_04235) 879777..881915 + 2139 WP_038879046.1 anaerobic ribonucleoside-triphosphate reductase -
OI978_RS04245 (OI978_04240) 882084..882548 + 465 WP_033636852.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OI978_RS04250 (OI978_04245) 882554..882829 - 276 WP_038879053.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
OI978_RS04255 (OI978_04250) 882838..883125 - 288 WP_013811307.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OI978_RS04260 (OI978_04255) 883231..884286 - 1056 WP_284596955.1 permease -
OI978_RS04265 (OI978_04260) 884514..885242 + 729 WP_047729221.1 phosphonate metabolism transcriptional regulator PhnF -
OI978_RS04270 (OI978_04265) 885243..885686 + 444 WP_019453314.1 phosphonate C-P lyase system protein PhnG -
OI978_RS04275 (OI978_04270) 885690..886271 + 582 WP_055317326.1 phosphonate C-P lyase system protein PhnH -
OI978_RS04280 (OI978_04275) 886271..887356 + 1086 WP_284596957.1 carbon-phosphorus lyase complex subunit PhnI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-70)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10736.52 Da        Isoelectric Point: 9.5103

>T262034 WP_038879053.1 NZ_CP109739:c882829-882554 [Serratia nevei]
MRIEWDNAALRDRERIFEFLYIFNPQAAVQADNEIDKAVKRLLDHPELGKPWYGKARKLLINKASLLLVYIIVDDVIKVF
SIAHQREKFPN

Download         Length: 276 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11032.33 Da        Isoelectric Point: 5.8001

>AT262034 WP_013811307.1 NZ_CP109739:c883125-882838 [Serratia nevei]
MESRIQFRIEDETKRLAQKAAEAKGTTLSEACRRLAEQMADEQRAAEEHENWLKDKVDAAFSRLHEGNAVYLSQQEVEES
MDAFKAKIRAKYDRK

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G3SNA4

Antitoxin

Source ID Structure
AlphaFold DB A0A086G7I5

References