Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3528083..3528733 Replicon chromosome
Accession NZ_CP109733
Organism Providencia thailandensis strain 2017-45-35

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag OI982_RS16645 Protein ID WP_284659473.1
Coordinates 3528083..3528286 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B2Q721
Locus tag OI982_RS16650 Protein ID WP_004927067.1
Coordinates 3528365..3528733 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI982_RS16620 (OI982_16770) 3523964..3524302 + 339 WP_004927053.1 P-II family nitrogen regulator -
OI982_RS16625 (OI982_16775) 3524313..3525596 + 1284 WP_014656764.1 ammonium transporter AmtB -
OI982_RS16630 (OI982_16780) 3525833..3526699 - 867 WP_284659472.1 acyl-CoA thioesterase II -
OI982_RS16635 (OI982_16785) 3527022..3527477 + 456 WP_284659610.1 YbaY family lipoprotein -
OI982_RS16645 (OI982_16795) 3528083..3528286 - 204 WP_284659473.1 HHA domain-containing protein Toxin
OI982_RS16650 (OI982_16800) 3528365..3528733 - 369 WP_004927067.1 Hha toxicity modulator TomB Antitoxin
OI982_RS16655 (OI982_16805) 3529301..3530638 - 1338 WP_004927077.1 murein transglycosylase D -
OI982_RS16660 (OI982_16810) 3530717..3531472 - 756 WP_076914490.1 hydroxyacylglutathione hydrolase -
OI982_RS16665 (OI982_16815) 3531506..3532231 + 726 WP_040132836.1 class I SAM-dependent methyltransferase -
OI982_RS16670 (OI982_16820) 3532310..3532780 - 471 WP_014656762.1 ribonuclease HI -
OI982_RS16675 (OI982_16825) 3532835..3533596 + 762 WP_004927092.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8101.45 Da        Isoelectric Point: 6.9770

>T262030 WP_284659473.1 NZ_CP109733:c3528286-3528083 [Providencia thailandensis]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSEDELELFYLAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14149.01 Da        Isoelectric Point: 4.2591

>AT262030 WP_004927067.1 NZ_CP109733:c3528733-3528365 [Providencia thailandensis]
MDEYSPKNYDISELKYLCNSLNREAMLSLQKTNTHWVNDLSSPQSARLNELIEHIAAFVWQFKIKYPKENLVISLVEEYL
DETYDLFGSPVITLSEIIDWQSMNQNLVSVLDDDLKCPASKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A140NKN2

References