Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4752968..4753625 Replicon chromosome
Accession NZ_CP109727
Organism Enterobacter roggenkampii strain 2017-45-51-04-01

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag OI980_RS23030 Protein ID WP_021242050.1
Coordinates 4752968..4753378 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W7NX65
Locus tag OI980_RS23035 Protein ID WP_006178375.1
Coordinates 4753359..4753625 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI980_RS23010 (OI980_23005) 4748961..4750694 - 1734 WP_045351724.1 single-stranded-DNA-specific exonuclease RecJ -
OI980_RS23015 (OI980_23010) 4750700..4751413 - 714 WP_008499708.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OI980_RS23020 (OI980_23015) 4751442..4752338 - 897 WP_045351722.1 site-specific tyrosine recombinase XerD -
OI980_RS23025 (OI980_23020) 4752440..4752961 + 522 WP_008499710.1 flavodoxin FldB -
OI980_RS23030 (OI980_23025) 4752968..4753378 - 411 WP_021242050.1 protein YgfX Toxin
OI980_RS23035 (OI980_23030) 4753359..4753625 - 267 WP_006178375.1 FAD assembly factor SdhE Antitoxin
OI980_RS23040 (OI980_23035) 4753920..4754900 + 981 WP_045351721.1 tRNA-modifying protein YgfZ -
OI980_RS23045 (OI980_23040) 4754985..4755644 - 660 WP_021242052.1 hemolysin III family protein -
OI980_RS23050 (OI980_23045) 4755910..4756641 + 732 WP_021242053.1 MurR/RpiR family transcriptional regulator -
OI980_RS23055 (OI980_23050) 4756758..4758191 + 1434 WP_008499715.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T262025 WP_021242050.1 NZ_CP109727:c4753378-4752968 [Enterobacter roggenkampii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1340

>AT262025 WP_006178375.1 NZ_CP109727:c4753625-4753359 [Enterobacter roggenkampii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB W7NX65

References