Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 2323908..2324705 Replicon chromosome
Accession NZ_CP109727
Organism Enterobacter roggenkampii strain 2017-45-51-04-01

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag OI980_RS11110 Protein ID WP_045352937.1
Coordinates 2324184..2324705 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID W7PG43
Locus tag OI980_RS11105 Protein ID WP_008499829.1
Coordinates 2323908..2324177 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI980_RS11070 (OI980_11065) 2319532..2319870 + 339 WP_241771488.1 Tox-REase-5 domain-containing protein -
OI980_RS11075 (OI980_11070) 2320255..2320629 + 375 WP_241771487.1 Imm52 family immunity protein -
OI980_RS11080 (OI980_11075) 2320630..2321307 + 678 Protein_2143 contractile injection system protein, VgrG/Pvc8 family -
OI980_RS11085 (OI980_11080) 2321403..2321630 - 228 WP_008499832.1 YccJ family protein -
OI980_RS11090 (OI980_11085) 2321651..2322247 - 597 WP_008499831.1 NAD(P)H:quinone oxidoreductase -
OI980_RS11095 (OI980_11090) 2322639..2322809 + 171 WP_013097201.1 general stress protein -
OI980_RS11100 (OI980_11095) 2322929..2323846 + 918 WP_025912980.1 DMT family transporter -
OI980_RS11105 (OI980_11100) 2323908..2324177 + 270 WP_008499829.1 DUF1778 domain-containing protein Antitoxin
OI980_RS11110 (OI980_11105) 2324184..2324705 + 522 WP_045352937.1 GNAT family N-acetyltransferase Toxin
OI980_RS11115 (OI980_11110) 2324779..2326101 - 1323 WP_045352935.1 pyrimidine utilization transport protein G -
OI980_RS11120 (OI980_11115) 2326123..2326617 - 495 WP_023292823.1 pyrimidine utilization flavin reductase protein F -
OI980_RS11125 (OI980_11120) 2326627..2327217 - 591 WP_025912982.1 malonic semialdehyde reductase -
OI980_RS11130 (OI980_11125) 2327227..2328027 - 801 WP_045352934.1 pyrimidine utilization protein D -
OI980_RS11135 (OI980_11130) 2328035..2328421 - 387 WP_008499822.1 pyrimidine utilization protein C -
OI980_RS11140 (OI980_11135) 2328433..2329122 - 690 WP_045352931.1 pyrimidine utilization protein B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19628.37 Da        Isoelectric Point: 7.4313

>T262020 WP_045352937.1 NZ_CP109727:2324184-2324705 [Enterobacter roggenkampii]
VDNLTIEMFSEGKDYDFRGFDCGEPSLNVFLTEHLVRQHNGRILRGYLLKDRDGPRVLGYYTLSGSCFEKAMLPSKTQQR
RIPYSNVPSVTLGRLAIHKDLQGLEWGTTLVTHAMRVAYLASQAVGVHGIFVDALNDQAKQFYLKQGFIPLTDENSHSLF
FPTKSIERLFEQA

Download         Length: 522 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10262.72 Da        Isoelectric Point: 5.8836

>AT262020 WP_008499829.1 NZ_CP109727:2323908-2324177 [Enterobacter roggenkampii]
MPALKKQRIDLRLTDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWNAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W7PG43

References