Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1671975..1672595 Replicon chromosome
Accession NZ_CP109727
Organism Enterobacter roggenkampii strain 2017-45-51-04-01

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag OI980_RS08020 Protein ID WP_008499287.1
Coordinates 1671975..1672193 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag OI980_RS08025 Protein ID WP_008499288.1
Coordinates 1672221..1672595 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI980_RS07990 (OI980_07990) 1667988..1668248 + 261 WP_006176933.1 type B 50S ribosomal protein L31 -
OI980_RS07995 (OI980_07995) 1668251..1668391 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
OI980_RS08000 (OI980_08000) 1668388..1669098 - 711 WP_045352701.1 GNAT family protein -
OI980_RS08005 (OI980_08005) 1669200..1670660 + 1461 WP_045352700.1 PLP-dependent aminotransferase family protein -
OI980_RS08010 (OI980_08010) 1670632..1671099 - 468 WP_008499285.1 YlaC family protein -
OI980_RS08015 (OI980_08015) 1671217..1671768 - 552 WP_008499286.1 maltose O-acetyltransferase -
OI980_RS08020 (OI980_08020) 1671975..1672193 - 219 WP_008499287.1 HHA domain-containing protein Toxin
OI980_RS08025 (OI980_08025) 1672221..1672595 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
OI980_RS08030 (OI980_08030) 1673105..1676251 - 3147 WP_045352698.1 multidrug efflux RND transporter permease subunit AcrB -
OI980_RS08035 (OI980_08035) 1676274..1677467 - 1194 WP_021241633.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T262018 WP_008499287.1 NZ_CP109727:c1672193-1671975 [Enterobacter roggenkampii]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT262018 WP_008499288.1 NZ_CP109727:c1672595-1672221 [Enterobacter roggenkampii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References