Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 1167530..1168106 Replicon chromosome
Accession NZ_CP109727
Organism Enterobacter roggenkampii strain 2017-45-51-04-01

Toxin (Protein)


Gene name shpA Uniprot ID A0A656ULU9
Locus tag OI980_RS05540 Protein ID WP_025912099.1
Coordinates 1167530..1167817 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A7D6YIG8
Locus tag OI980_RS05545 Protein ID WP_025912101.1
Coordinates 1167804..1168106 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI980_RS05510 (OI980_05510) 1162773..1162889 + 117 Protein_1057 amino acid-binding protein -
OI980_RS05515 (OI980_05515) 1162882..1163347 + 466 Protein_1058 winged helix-turn-helix domain-containing protein -
OI980_RS05520 (OI980_05520) 1163493..1163963 + 471 WP_021240623.1 MarR family transcriptional regulator -
OI980_RS05525 (OI980_05525) 1163960..1165027 + 1068 WP_025912094.1 HlyD family secretion protein -
OI980_RS05530 (OI980_05530) 1165017..1166093 + 1077 WP_032655052.1 DUF2955 domain-containing protein -
OI980_RS05535 (OI980_05535) 1166090..1167361 - 1272 WP_045353153.1 DUF445 domain-containing protein -
OI980_RS05540 (OI980_05540) 1167530..1167817 + 288 WP_025912099.1 BrnT family toxin Toxin
OI980_RS05545 (OI980_05545) 1167804..1168106 + 303 WP_025912101.1 BrnA antitoxin family protein Antitoxin
OI980_RS05550 (OI980_05550) 1168137..1168775 - 639 WP_045353154.1 LysE family translocator -
OI980_RS05555 (OI980_05555) 1168823..1169566 - 744 WP_045353155.1 AraC family transcriptional regulator -
OI980_RS05560 (OI980_05560) 1169718..1171088 + 1371 WP_045353156.1 NAD-dependent succinate-semialdehyde dehydrogenase -
OI980_RS05565 (OI980_05565) 1171134..1171454 - 321 WP_008501314.1 hypothetical protein -
OI980_RS05570 (OI980_05570) 1171454..1171999 - 546 WP_008501313.1 YfaZ family outer membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11235.68 Da        Isoelectric Point: 7.4007

>T262017 WP_025912099.1 NZ_CP109727:1167530-1167817 [Enterobacter roggenkampii]
MPTEYEWDSNKAKSNLQKHGIRFEDAVMVFDDPYHLSVQDRYENGEFRWQTIGLVQGLLVILVAHTVRFESGGEIIRIIS
ARKADRKERSRYEHR

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11413.02 Da        Isoelectric Point: 10.0592

>AT262017 WP_025912101.1 NZ_CP109727:1167804-1168106 [Enterobacter roggenkampii]
MSIVKHKRGSAPEVSARREAELKALAEKPEAEIDYSDIPATDDEQWSGAVRGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656ULU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7D6YIG8

References