Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 836348..836944 Replicon chromosome
Accession NZ_CP109727
Organism Enterobacter roggenkampii strain 2017-45-51-04-01

Toxin (Protein)


Gene name PumA Uniprot ID A0A0F1DED9
Locus tag OI980_RS03935 Protein ID WP_023293553.1
Coordinates 836642..836944 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID W7P674
Locus tag OI980_RS03930 Protein ID WP_021242718.1
Coordinates 836348..836635 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI980_RS03925 (OI980_03925) 834720..836351 + 1632 WP_008503411.1 Na/Pi cotransporter family protein -
OI980_RS03930 (OI980_03930) 836348..836635 - 288 WP_021242718.1 putative addiction module antidote protein Antitoxin
OI980_RS03935 (OI980_03935) 836642..836944 - 303 WP_023293553.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OI980_RS03940 (OI980_03940) 837142..838014 + 873 WP_045352872.1 23S rRNA pseudouridine(2604) synthase RluF -
OI980_RS03945 (OI980_03945) 838015..838287 - 273 WP_014830263.1 DUF3811 domain-containing protein -
OI980_RS03950 (OI980_03950) 838338..839282 - 945 WP_023293551.1 ketopantoate/pantoate/pantothenate transporter PanS -
OI980_RS03955 (OI980_03955) 839388..840962 - 1575 WP_032654615.1 RNA repair transcriptional activator RtcR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-93)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11459.24 Da        Isoelectric Point: 10.1771

>T262016 WP_023293553.1 NZ_CP109727:c836944-836642 [Enterobacter roggenkampii]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDVKPVGEGISELRIHFGPGYRIYFKDQGNYIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10156.57 Da        Isoelectric Point: 6.4596

>AT262016 WP_021242718.1 NZ_CP109727:c836635-836348 [Enterobacter roggenkampii]
MHKLTPYDPANALVDDEEIAVFIADALETGDSTYIAKALGVVARAKGMSNISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGFGLTLKHAGD

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F1DED9

Antitoxin

Source ID Structure
AlphaFold DB W7P674

References