Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 40486..41225 Replicon plasmid p2017-45-54-05_2
Accession NZ_CP109697
Organism Enterobacter asburiae strain 2017-45-54-05

Toxin (Protein)


Gene name tacT Uniprot ID A0A5E1AVR5
Locus tag OI909_RS24935 Protein ID WP_013087172.1
Coordinates 40486..40971 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A5E1AWX8
Locus tag OI909_RS24940 Protein ID WP_012540086.1
Coordinates 40959..41225 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI909_RS24915 (OI909_24910) 36476..36745 + 270 WP_004196355.1 nickel-sensing transcriptional repressor NcrB -
OI909_RS24920 (OI909_24915) 36758..37888 + 1131 WP_004196366.1 Ni(II)/Co(II) efflux transporter permease subunit NcrC -
OI909_RS24925 (OI909_24920) 38050..38472 + 423 WP_032072095.1 nickel resistance OB fold protein NcrY -
OI909_RS24930 (OI909_24925) 38728..40068 - 1341 WP_004196353.1 IS1202-like element ISEsa1 family transposase -
OI909_RS24935 (OI909_24930) 40486..40971 - 486 WP_013087172.1 GNAT family N-acetyltransferase Toxin
OI909_RS24940 (OI909_24935) 40959..41225 - 267 WP_012540086.1 DUF1778 domain-containing protein Antitoxin
OI909_RS24945 (OI909_24940) 41525..41848 + 324 WP_013087171.1 metalloregulator ArsR/SmtB family transcription factor -
OI909_RS24950 (OI909_24945) 41850..42563 + 714 Protein_61 arsenical resistance protein ArsH -
OI909_RS24955 (OI909_24950) 42572..43117 + 546 WP_013087169.1 sigma-70 family RNA polymerase sigma factor -
OI909_RS24960 (OI909_24955) 43193..43555 + 363 WP_013087168.1 arsenic metallochaperone ArsD family protein -
OI909_RS24965 (OI909_24960) 43576..45333 + 1758 WP_013087167.1 arsenical pump-driving ATPase -
OI909_RS24970 (OI909_24965) 45458..45994 + 537 WP_013087166.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..125451 125451


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-152)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17810.62 Da        Isoelectric Point: 9.8560

>T262013 WP_013087172.1 NZ_CP109697:c40971-40486 [Enterobacter asburiae]
VGRVTVPEPLSSFHQVAEFVCGETVLDDWLKQKGLKNQALGSARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQQRTLFLKLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10076.47 Da        Isoelectric Point: 4.3721

>AT262013 WP_012540086.1 NZ_CP109697:c41225-40959 [Enterobacter asburiae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIDKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5E1AVR5

Antitoxin

Source ID Structure
AlphaFold DB A0A5E1AWX8

References