Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 27359..27885 Replicon plasmid p2017-45-54-05_2
Accession NZ_CP109697
Organism Enterobacter asburiae strain 2017-45-54-05

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag OI909_RS24850 Protein ID WP_000323025.1
Coordinates 27359..27646 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J5W3H0
Locus tag OI909_RS24855 Protein ID WP_004196370.1
Coordinates 27646..27885 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI909_RS24815 (OI909_24810) 22830..23117 - 288 WP_047345096.1 hypothetical protein -
OI909_RS24820 (OI909_24815) 23196..23987 - 792 WP_013087183.1 N-6 DNA methylase -
OI909_RS24825 (OI909_24820) 24028..24228 - 201 WP_013087182.1 hypothetical protein -
OI909_RS24830 (OI909_24825) 24316..24777 - 462 WP_013087181.1 hypothetical protein -
OI909_RS24835 (OI909_24830) 24838..25152 - 315 WP_047345097.1 hypothetical protein -
OI909_RS24840 (OI909_24835) 26032..26142 - 111 WP_230678187.1 DUF5431 family protein -
OI909_RS24845 (OI909_24840) 26258..27292 + 1035 Protein_40 IS481 family transposase -
OI909_RS24850 (OI909_24845) 27359..27646 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
OI909_RS24855 (OI909_24850) 27646..27885 - 240 WP_004196370.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
OI909_RS24860 (OI909_24855) 27910..28008 + 99 Protein_43 protein YdfV -
OI909_RS24865 (OI909_24860) 28136..28501 + 366 WP_009651956.1 hypothetical protein -
OI909_RS24870 (OI909_24865) 28545..29282 + 738 WP_008460272.1 HupE/UreJ family protein -
OI909_RS24875 (OI909_24870) 29296..29985 + 690 WP_004196322.1 hypothetical protein -
OI909_RS24880 (OI909_24875) 30016..31392 - 1377 WP_004196363.1 chromate efflux transporter -
OI909_RS24885 (OI909_24880) 31349..32326 - 978 WP_004196334.1 chromate resistance protein -
OI909_RS24890 (OI909_24885) 32356..32548 + 193 Protein_49 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..125451 125451


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T262012 WP_000323025.1 NZ_CP109697:c27646-27359 [Enterobacter asburiae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9018.43 Da        Isoelectric Point: 4.3894

>AT262012 WP_004196370.1 NZ_CP109697:c27885-27646 [Enterobacter asburiae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4QRH4

References