Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4833850..4834426 Replicon chromosome
Accession NZ_CP109694
Organism Enterobacter asburiae strain 2017-45-54-05

Toxin (Protein)


Gene name shpA Uniprot ID A0A4R0G892
Locus tag OI909_RS23525 Protein ID WP_010427219.1
Coordinates 4833850..4834137 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID -
Locus tag OI909_RS23530 Protein ID WP_048976412.1
Coordinates 4834124..4834426 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI909_RS23500 (OI909_23495) 4828966..4829661 + 696 WP_182072048.1 winged helix-turn-helix domain-containing protein -
OI909_RS23505 (OI909_23500) 4829811..4830281 + 471 WP_033144545.1 MarR family transcriptional regulator -
OI909_RS23510 (OI909_23505) 4830278..4831345 + 1068 WP_127353288.1 HlyD family secretion protein -
OI909_RS23515 (OI909_23510) 4831335..4832411 + 1077 WP_023310256.1 DUF2955 domain-containing protein -
OI909_RS23520 (OI909_23515) 4832408..4833679 - 1272 WP_039260963.1 DUF445 domain-containing protein -
OI909_RS23525 (OI909_23520) 4833850..4834137 + 288 WP_010427219.1 BrnT family toxin Toxin
OI909_RS23530 (OI909_23525) 4834124..4834426 + 303 WP_048976412.1 BrnA antitoxin family protein Antitoxin
OI909_RS23535 (OI909_23530) 4834457..4835095 - 639 WP_182072050.1 LysE family translocator -
OI909_RS23540 (OI909_23535) 4835143..4835886 - 744 WP_182072052.1 AraC family transcriptional regulator -
OI909_RS23545 (OI909_23540) 4836038..4837408 + 1371 WP_182072054.1 NAD-dependent succinate-semialdehyde dehydrogenase -
OI909_RS23550 (OI909_23545) 4837453..4837773 - 321 WP_182072056.1 hypothetical protein -
OI909_RS23555 (OI909_23550) 4837773..4838318 - 546 WP_023310269.1 YfaZ family outer membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11174.64 Da        Isoelectric Point: 6.7609

>T262010 WP_010427219.1 NZ_CP109694:4833850-4834137 [Enterobacter asburiae]
MPTEFEWDTNKAKSNLIKHGIRFEEAVLVFDDPYHLSLQDRHENGEFRWQTIGLVHGLIVIMVAHTVRFESGDEVIRIIS
ARKADRKERSRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11497.19 Da        Isoelectric Point: 10.0592

>AT262010 WP_048976412.1 NZ_CP109694:4834124-4834426 [Enterobacter asburiae]
MSMVKHKRGSAPEMSARREAELKALAEKSEAEIDYSDIPAMEDEQWSGAVRGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4R0G892

Antitoxin

Source ID Structure

References