Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 4283303..4283965 Replicon chromosome
Accession NZ_CP109694
Organism Enterobacter asburiae strain 2017-45-54-05

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag OI909_RS20925 Protein ID WP_176686521.1
Coordinates 4283567..4283965 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag OI909_RS20920 Protein ID WP_182072104.1
Coordinates 4283303..4283563 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI909_RS20905 (OI909_20900) 4280728..4281849 - 1122 WP_284592962.1 efflux RND transporter periplasmic adaptor subunit -
OI909_RS20910 (OI909_20905) 4281998..4282567 - 570 WP_033144322.1 helix-turn-helix domain-containing protein -
OI909_RS20915 (OI909_20910) 4282754..4283173 + 420 WP_182072102.1 GNAT family N-acetyltransferase -
OI909_RS20920 (OI909_20915) 4283303..4283563 + 261 WP_182072104.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
OI909_RS20925 (OI909_20920) 4283567..4283965 + 399 WP_176686521.1 type II toxin-antitoxin system VapC family toxin Toxin
OI909_RS20930 (OI909_20925) 4284106..4284906 + 801 WP_182072106.1 lipoprotein NlpA -
OI909_RS20935 (OI909_20930) 4285029..4285808 + 780 WP_182072108.1 MBL fold metallo-hydrolase -
OI909_RS20940 (OI909_20935) 4285835..4286788 + 954 WP_182072110.1 helix-turn-helix domain-containing protein -
OI909_RS20945 (OI909_20940) 4286972..4288669 + 1698 WP_233476967.1 ShlB/FhaC/HecB family hemolysin secretion/activation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14961.16 Da        Isoelectric Point: 6.0840

>T262008 WP_176686521.1 NZ_CP109694:4283567-4283965 [Enterobacter asburiae]
MLHMLDTNMVSHLVRQHPGVLEQYSRTPTEKMCISSVTEAELLYGIAKKQNDTLQKTILEFLKTITICDWDSDAAATYGE
LRAAMEKRGKVMGDLDQLIAAHAISRRTTIVTNDRAFRMVQELTVEDWTTTS

Download         Length: 399 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10176.44 Da        Isoelectric Point: 8.5750

>AT262008 WP_182072104.1 NZ_CP109694:4283303-4283563 [Enterobacter asburiae]
MERTAKLFKKGRNQAVMIPAEFAFDTESVYIRRDEEGNVVLTARSEKERHRDNFLRLLKQTHVPDSFLSKEERNQSYTTR
DPFEGL

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References