Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 2458277..2458867 Replicon chromosome
Accession NZ_CP109694
Organism Enterobacter asburiae strain 2017-45-54-05

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag OI909_RS12125 Protein ID WP_058841450.1
Coordinates 2458277..2458609 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag OI909_RS12130 Protein ID WP_058841451.1
Coordinates 2458610..2458867 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI909_RS12110 (OI909_12105) 2454441..2455766 + 1326 WP_182072112.1 SidA/IucD/PvdA family monooxygenase -
OI909_RS12115 (OI909_12110) 2455793..2457982 + 2190 WP_047061141.1 TonB-dependent siderophore receptor -
OI909_RS12125 (OI909_12120) 2458277..2458609 - 333 WP_058841450.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OI909_RS12130 (OI909_12125) 2458610..2458867 - 258 WP_058841451.1 hypothetical protein Antitoxin
OI909_RS12135 (OI909_12130) 2459159..2459548 - 390 WP_096150847.1 RidA family protein -
OI909_RS12140 (OI909_12135) 2459690..2460610 + 921 WP_048980124.1 LysR family transcriptional regulator -
OI909_RS12145 (OI909_12140) 2460686..2460988 - 303 WP_029741460.1 XRE family transcriptional regulator -
OI909_RS12150 (OI909_12145) 2460993..2461346 - 354 WP_048980127.1 type II toxin-antitoxin system RelE/ParE family toxin -
OI909_RS12155 (OI909_12150) 2461524..2462417 - 894 WP_048980130.1 LysR substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11757.57 Da        Isoelectric Point: 9.4051

>T262003 WP_058841450.1 NZ_CP109694:c2458609-2458277 [Enterobacter asburiae]
MDRGEIWLVSLDPIAGHEQSGKRPVLVVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEGAGTTTTGVIRCDQPRTI
DMAARNGMRLERIPDAVVNEVLARLDAILS

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9490.96 Da        Isoelectric Point: 4.3351

>AT262003 WP_058841451.1 NZ_CP109694:c2458867-2458610 [Enterobacter asburiae]
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTINNGCLIIEPQKRPHYSLEELLAQCDPYAEMSEEEREWIDAPAV
GREIL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References