Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 1081096..1081893 Replicon chromosome
Accession NZ_CP109694
Organism Enterobacter asburiae strain 2017-45-54-05

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag OI909_RS05225 Protein ID WP_172421424.1
Coordinates 1081393..1081893 (+) Length 167 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID W7PG43
Locus tag OI909_RS05220 Protein ID WP_008499829.1
Coordinates 1081096..1081365 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI909_RS05190 (OI909_05185) 1076723..1077166 - 444 WP_032658095.1 helix-turn-helix domain-containing protein -
OI909_RS05195 (OI909_05190) 1077319..1078560 + 1242 WP_182071674.1 bifunctional glucose-1-phosphatase/inositol phosphatase -
OI909_RS05200 (OI909_05195) 1078594..1078821 - 228 WP_008499832.1 YccJ family protein -
OI909_RS05205 (OI909_05200) 1078842..1079438 - 597 WP_023311076.1 NAD(P)H:quinone oxidoreductase -
OI909_RS05210 (OI909_05205) 1079829..1079999 + 171 WP_023311077.1 general stress protein -
OI909_RS05215 (OI909_05210) 1080117..1081034 + 918 WP_284593221.1 DMT family transporter -
OI909_RS05220 (OI909_05215) 1081096..1081365 + 270 WP_008499829.1 DUF1778 domain-containing protein Antitoxin
OI909_RS05225 (OI909_05220) 1081393..1081893 + 501 WP_172421424.1 GNAT family N-acetyltransferase Toxin
OI909_RS05230 (OI909_05225) 1081967..1083289 - 1323 WP_182071673.1 pyrimidine utilization transport protein G -
OI909_RS05235 (OI909_05230) 1083311..1083805 - 495 WP_032658088.1 pyrimidine utilization flavin reductase protein F -
OI909_RS05240 (OI909_05235) 1083815..1084405 - 591 WP_047061542.1 malonic semialdehyde reductase -
OI909_RS05245 (OI909_05240) 1084415..1085215 - 801 WP_182071672.1 pyrimidine utilization protein D -
OI909_RS05250 (OI909_05245) 1085223..1085609 - 387 WP_010429508.1 pyrimidine utilization protein C -
OI909_RS05255 (OI909_05250) 1085621..1086310 - 690 WP_182071671.1 pyrimidine utilization protein B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 18969.67 Da        Isoelectric Point: 7.9145

>T261998 WP_172421424.1 NZ_CP109694:1081393-1081893 [Enterobacter asburiae]
MLSEGTDYDFEDFDCGEPSLNAFLAEHLVRQHNGRILRAYLLKERDRPRVLGYYTLSGSCFERAMLPSKTQQRRIPYINV
PSVTLGRLAVDKTLQGNEWGTTLVAHAMRVVYLASQAVGVHGIFVDALNERAKRFYLKQGFIPLTAENSHSLFFPTKSIE
RLFEQE

Download         Length: 501 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10262.72 Da        Isoelectric Point: 5.8836

>AT261998 WP_008499829.1 NZ_CP109694:1081096-1081365 [Enterobacter asburiae]
MPALKKQRIDLRLTDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWNAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W7PG43

References