Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 9707..10233 Replicon plasmid p2017-45-80_1
Accession NZ_CP109693
Organism Enterobacter asburiae strain 2017-45-80

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag OI907_RS22905 Protein ID WP_000323025.1
Coordinates 9946..10233 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag OI907_RS22900 Protein ID WP_000534858.1
Coordinates 9707..9946 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI907_RS22870 (4942) 4942..5316 + 375 WP_023327673.1 hypothetical protein -
- (5376) 5376..5470 + 95 NuclAT_0 - -
- (5376) 5376..5470 + 95 NuclAT_0 - -
- (5376) 5376..5470 + 95 NuclAT_0 - -
- (5376) 5376..5470 + 95 NuclAT_0 - -
OI907_RS22875 (5520) 5520..6889 + 1370 WP_085949440.1 IS3-like element ISKpn8 family transposase -
OI907_RS22880 (6932) 6932..7009 + 78 WP_158409081.1 DUF5431 family protein -
OI907_RS22885 (7065) 7065..8405 + 1341 WP_004196353.1 IS1202-like element ISEsa1 family transposase -
OI907_RS22890 (8842) 8842..9174 - 333 WP_001317460.1 FlxA-like family protein -
OI907_RS22895 (9377) 9377..9682 - 306 WP_001326990.1 protein YdfV -
OI907_RS22900 (9707) 9707..9946 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
OI907_RS22905 (9946) 9946..10233 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
OI907_RS22910 (10305) 10305..10463 + 159 WP_008325141.1 type I toxin-antitoxin system Hok family toxin -
OI907_RS22915 (11336) 11336..11629 + 294 WP_023327733.1 hypothetical protein -
OI907_RS22920 (11646) 11646..12467 + 822 WP_023327732.1 DUF932 domain-containing protein -
OI907_RS22925 (12496) 12496..13035 - 540 WP_032636190.1 lytic transglycosylase domain-containing protein -
OI907_RS22930 (13609) 13609..14004 + 396 WP_023327730.1 hypothetical protein -
OI907_RS22935 (14037) 14037..14678 - 642 WP_032636186.1 Arc family DNA-binding protein -
OI907_RS22940 (14875) 14875..15228 + 354 WP_033147099.1 type IV conjugative transfer system pilin TraA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..79034 79034


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T261995 WP_000323025.1 NZ_CP109693:9946-10233 [Enterobacter asburiae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT261995 WP_000534858.1 NZ_CP109693:9707-9946 [Enterobacter asburiae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References