Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 4394921..4395511 Replicon chromosome
Accession NZ_CP109692
Organism Enterobacter asburiae strain 2017-45-80

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag OI907_RS21615 Protein ID WP_033145927.1
Coordinates 4395179..4395511 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag OI907_RS21610 Protein ID WP_033145928.1
Coordinates 4394921..4395178 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI907_RS21580 (OI907_21560) 4390592..4391200 - 609 WP_080277780.1 glutathione S-transferase family protein -
OI907_RS21585 (OI907_21565) 4391371..4392264 + 894 WP_033145932.1 LysR substrate-binding domain-containing protein -
OI907_RS21590 (OI907_21570) 4392442..4392795 + 354 WP_033145931.1 type II toxin-antitoxin system RelE/ParE family toxin -
OI907_RS21595 (OI907_21575) 4392800..4393102 + 303 WP_029741460.1 XRE family transcriptional regulator -
OI907_RS21600 (OI907_21580) 4393178..4394098 - 921 WP_033145930.1 LysR family transcriptional regulator -
OI907_RS21605 (OI907_21585) 4394240..4394629 + 390 WP_033145929.1 RidA family protein -
OI907_RS21610 (OI907_21590) 4394921..4395178 + 258 WP_033145928.1 antitoxin Antitoxin
OI907_RS21615 (OI907_21595) 4395179..4395511 + 333 WP_033145927.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OI907_RS21620 (OI907_21600) 4395468..4395662 - 195 WP_080277779.1 hypothetical protein -
OI907_RS21625 (OI907_21605) 4395832..4397193 - 1362 WP_003036316.1 HEPN/Toprim-associated domain-containing protein -
OI907_RS21630 (OI907_21610) 4398029..4398967 + 939 WP_003036321.1 hypothetical protein -
OI907_RS21635 (OI907_21615) 4399043..4399525 + 483 WP_003036324.1 hypothetical protein -
OI907_RS21640 (OI907_21620) 4399547..4400350 + 804 WP_003036327.1 TIGR02391 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4383912..4412537 28625


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11828.65 Da        Isoelectric Point: 9.4051

>T261990 WP_033145927.1 NZ_CP109692:4395179-4395511 [Enterobacter asburiae]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEGAGTTTTGVIRCDQPRTI
DMSARNGMRLERIPDAVINEVLARLDAILN

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9464.92 Da        Isoelectric Point: 4.4737

>AT261990 WP_033145928.1 NZ_CP109692:4394921-4395178 [Enterobacter asburiae]
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTINNGCLIIEPQKRPHYSLEELLAQCDPHAEMSEEEREWIDAPAV
GREIL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References