Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2674831..2675447 Replicon chromosome
Accession NZ_CP109692
Organism Enterobacter asburiae strain 2017-45-80

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag OI907_RS13170 Protein ID WP_080277799.1
Coordinates 2675076..2675447 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag OI907_RS13165 Protein ID WP_033146961.1
Coordinates 2674831..2675073 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI907_RS13135 (OI907_13120) 2670249..2670719 + 471 WP_033146967.1 hypothetical protein -
OI907_RS13140 (OI907_13125) 2670808..2671407 + 600 WP_033146966.1 glucose-1-phosphatase -
OI907_RS13145 (OI907_13130) 2671401..2672282 + 882 WP_033146965.1 virulence factor BrkB family protein -
OI907_RS13150 (OI907_13135) 2672279..2672716 + 438 WP_033146964.1 D-aminoacyl-tRNA deacylase -
OI907_RS13155 (OI907_13140) 2672761..2673702 + 942 WP_033146963.1 fatty acid biosynthesis protein FabY -
OI907_RS13160 (OI907_13145) 2673711..2674631 - 921 WP_033146962.1 alpha/beta hydrolase -
OI907_RS13165 (OI907_13150) 2674831..2675073 + 243 WP_033146961.1 CopG family transcriptional regulator Antitoxin
OI907_RS13170 (OI907_13155) 2675076..2675447 + 372 WP_080277799.1 type II toxin-antitoxin system VapC family toxin Toxin
OI907_RS13175 (OI907_13160) 2675487..2676416 - 930 WP_023309751.1 formate dehydrogenase accessory protein FdhE -
OI907_RS13180 (OI907_13165) 2676413..2677048 - 636 WP_010436852.1 formate dehydrogenase cytochrome b556 subunit -
OI907_RS13185 (OI907_13170) 2677045..2677947 - 903 WP_010436855.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-109)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13687.90 Da        Isoelectric Point: 6.9789

>T261985 WP_080277799.1 NZ_CP109692:2675076-2675447 [Enterobacter asburiae]
MEHMAVFDTNILIDLFNNRVEAADAIDRTASHRAISLITWMEVMVGARKHGHEAKTATVMGVFEIIDITRDIAERSVILR
EKHGMKLPDAIILATAQSRSCPLISRNTKDFLGITGVVSPYQL

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9469.67 Da        Isoelectric Point: 4.2917

>AT261985 WP_033146961.1 NZ_CP109692:2674831-2675073 [Enterobacter asburiae]
MILSADLDMGRILIDLSEDVIQRLDNLKQLRNRPRAELLREAIEQYLDQQSSSVIRDALGLWGNQQEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References