Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 2339495..2340087 Replicon chromosome
Accession NZ_CP109692
Organism Enterobacter asburiae strain 2017-45-80

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag OI907_RS11655 Protein ID WP_033144376.1
Coordinates 2339495..2339797 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A808IFF3
Locus tag OI907_RS11660 Protein ID WP_033144375.1
Coordinates 2339800..2340087 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI907_RS11635 (OI907_11620) 2335714..2337063 + 1350 WP_033144379.1 lysine-sensitive aspartokinase 3 -
OI907_RS11640 (OI907_11625) 2337157..2338101 + 945 WP_033144378.1 ketopantoate/pantoate/pantothenate transporter PanS -
OI907_RS11645 (OI907_11630) 2338152..2338424 + 273 WP_023309994.1 DUF3811 domain-containing protein -
OI907_RS11650 (OI907_11635) 2338425..2339297 - 873 WP_033144377.1 23S rRNA pseudouridine(2604) synthase RluF -
OI907_RS11655 (OI907_11640) 2339495..2339797 + 303 WP_033144376.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OI907_RS11660 (OI907_11645) 2339800..2340087 + 288 WP_033144375.1 putative addiction module antidote protein Antitoxin
OI907_RS11665 (OI907_11650) 2340084..2341715 - 1632 WP_033144374.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-93)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11284.02 Da        Isoelectric Point: 9.9325

>T261983 WP_033144376.1 NZ_CP109692:2339495-2339797 [Enterobacter asburiae]
MKEIVQTESFQRWEQNLKDRRAKTIIASRLFRLANGLAGDIKPVGEGISELRIHYGPGYRIYFKDQGNCIIVLLCGGDKS
SQARDILMAKMLSNPNGRSE

Download         Length: 303 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10111.59 Da        Isoelectric Point: 6.4596

>AT261983 WP_033144375.1 NZ_CP109692:2339800-2340087 [Enterobacter asburiae]
MHKLTPYDPANALVDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKHAGD

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A808IFF3

References