Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2087282..2087798 Replicon chromosome
Accession NZ_CP109692
Organism Enterobacter asburiae strain 2017-45-80

Toxin (Protein)


Gene name relE Uniprot ID A0A7W2VUY1
Locus tag OI907_RS10430 Protein ID WP_033144499.1
Coordinates 2087282..2087566 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V3EXX3
Locus tag OI907_RS10435 Protein ID WP_008501400.1
Coordinates 2087556..2087798 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI907_RS10415 (OI907_10400) 2082514..2084157 + 1644 WP_033144501.1 alpha,alpha-phosphotrehalase -
OI907_RS10420 (OI907_10405) 2084534..2086672 + 2139 WP_032662478.1 anaerobic ribonucleoside-triphosphate reductase -
OI907_RS10425 (OI907_10410) 2086814..2087278 + 465 WP_033144500.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OI907_RS10430 (OI907_10415) 2087282..2087566 - 285 WP_033144499.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OI907_RS10435 (OI907_10420) 2087556..2087798 - 243 WP_008501400.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OI907_RS10440 (OI907_10425) 2087876..2089786 - 1911 WP_033144498.1 PRD domain-containing protein -
OI907_RS10445 (OI907_10430) 2089806..2090942 - 1137 WP_033144497.1 lactonase family protein -
OI907_RS10450 (OI907_10435) 2091057..2091797 - 741 WP_033144496.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10866.68 Da        Isoelectric Point: 10.3350

>T261982 WP_033144499.1 NZ_CP109692:c2087566-2087282 [Enterobacter asburiae]
MTYELAFDPRALKEWSKLGQTVKDQFKKKLADVLVSPRVESARLHGLPDCYKIKLRSQGYRLVYQVQDNVVTVFVIAIGK
REKSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8972.37 Da        Isoelectric Point: 5.0651

>AT261982 WP_008501400.1 NZ_CP109692:c2087798-2087556 [Enterobacter asburiae]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDALIQTVRERLANPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W2VUY1

Antitoxin

Source ID Structure
AlphaFold DB V3EXX3

References