Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 2000492..2001068 Replicon chromosome
Accession NZ_CP109692
Organism Enterobacter asburiae strain 2017-45-80

Toxin (Protein)


Gene name shpA Uniprot ID A0A4R0G892
Locus tag OI907_RS10030 Protein ID WP_010427219.1
Coordinates 2000781..2001068 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A411GC49
Locus tag OI907_RS10025 Protein ID WP_033144548.1
Coordinates 2000492..2000794 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI907_RS10000 (OI907_09985) 1996598..1997143 + 546 WP_023310269.1 YfaZ family outer membrane protein -
OI907_RS10005 (OI907_09990) 1997143..1997463 + 321 WP_033144551.1 hypothetical protein -
OI907_RS10010 (OI907_09995) 1997510..1998880 - 1371 WP_033144550.1 NAD-dependent succinate-semialdehyde dehydrogenase -
OI907_RS10015 (OI907_10000) 1999032..1999775 + 744 WP_033146481.1 AraC family transcriptional regulator -
OI907_RS10020 (OI907_10005) 1999823..2000461 + 639 WP_033144549.1 LysE family translocator -
OI907_RS10025 (OI907_10010) 2000492..2000794 - 303 WP_033144548.1 BrnA antitoxin family protein Antitoxin
OI907_RS10030 (OI907_10015) 2000781..2001068 - 288 WP_010427219.1 BrnT family toxin Toxin
OI907_RS10035 (OI907_10020) 2001239..2002510 + 1272 WP_033144547.1 DUF445 domain-containing protein -
OI907_RS10040 (OI907_10025) 2002507..2003583 - 1077 WP_023310256.1 DUF2955 domain-containing protein -
OI907_RS10045 (OI907_10030) 2003573..2004640 - 1068 WP_101744430.1 HlyD family secretion protein -
OI907_RS10050 (OI907_10035) 2004637..2005107 - 471 WP_033144545.1 MarR family transcriptional regulator -
OI907_RS10055 (OI907_10040) 2005257..2005952 - 696 WP_033144544.1 winged helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(32-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11174.64 Da        Isoelectric Point: 6.7609

>T261981 WP_010427219.1 NZ_CP109692:c2001068-2000781 [Enterobacter asburiae]
MPTEFEWDTNKAKSNLIKHGIRFEEAVLVFDDPYHLSLQDRHENGEFRWQTIGLVHGLIVIMVAHTVRFESGDEVIRIIS
ARKADRKERSRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11395.04 Da        Isoelectric Point: 10.2483

>AT261981 WP_033144548.1 NZ_CP109692:c2000794-2000492 [Enterobacter asburiae]
MSMVKHKRGSAPEMSARREAELKALAEKSEAEIDYSDIPATGDEQWSGAVRGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4R0G892

Antitoxin

Source ID Structure
AlphaFold DB A0A411GC49

References