Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1534055..1534675 Replicon chromosome
Accession NZ_CP109692
Organism Enterobacter asburiae strain 2017-45-80

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag OI907_RS07825 Protein ID WP_008499287.1
Coordinates 1534457..1534675 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag OI907_RS07820 Protein ID WP_008499288.1
Coordinates 1534055..1534429 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI907_RS07810 (OI907_07795) 1529181..1530374 + 1194 WP_029741963.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
OI907_RS07815 (OI907_07800) 1530397..1533543 + 3147 WP_029741964.1 multidrug efflux RND transporter permease subunit AcrB -
OI907_RS07820 (OI907_07805) 1534055..1534429 + 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
OI907_RS07825 (OI907_07810) 1534457..1534675 + 219 WP_008499287.1 HHA domain-containing protein Toxin
OI907_RS07830 (OI907_07815) 1534881..1535432 + 552 WP_033144790.1 maltose O-acetyltransferase -
OI907_RS07835 (OI907_07820) 1535550..1536017 + 468 WP_023310598.1 YlaC family protein -
OI907_RS07840 (OI907_07825) 1535989..1537449 - 1461 WP_033144789.1 PLP-dependent aminotransferase family protein -
OI907_RS07845 (OI907_07830) 1537551..1538261 + 711 WP_033144788.1 GNAT family protein -
OI907_RS07850 (OI907_07835) 1538258..1538398 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
OI907_RS07855 (OI907_07840) 1538401..1538661 - 261 WP_010428154.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T261980 WP_008499287.1 NZ_CP109692:1534457-1534675 [Enterobacter asburiae]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T261980 NZ_CP109692:1534457-1534675 [Enterobacter asburiae]
ATGTCTGATAAACCACTCACAAAAATCGATTATTTGATGCGCTTACGGCGTTGTCAGTCAATTGACACGCTTGAGCGCGT
CATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCGGTATTTTATTCAGCCGCTGACCATCGTCTTGCTGAAC
TGACAATGAATAAACTGTATGACAAAATCCCTACTTCTGTGTGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT261980 WP_008499288.1 NZ_CP109692:1534055-1534429 [Enterobacter asburiae]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT261980 NZ_CP109692:1534055-1534429 [Enterobacter asburiae]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGTAACCATGGCTGGGTAAACGACCCAACATCTGCCATCAATTTACAGTTGAATGAGCTGATAGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTCATTGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGTTACGGCATTAACGCGCAGGATTTGCAAAAATGGCGTAAATCGGGAAATCGGCT
ATTCCGCTGTTTCGTCAACGTGAGCAGAGCTAACCCGGTGAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References