Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 957547..958344 Replicon chromosome
Accession NZ_CP109692
Organism Enterobacter asburiae strain 2017-45-80

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag OI907_RS05055 Protein ID WP_172421424.1
Coordinates 957547..958047 (-) Length 167 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID W7PG43
Locus tag OI907_RS05060 Protein ID WP_008499829.1
Coordinates 958075..958344 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI907_RS05025 (OI907_05015) 953130..953819 + 690 WP_033145167.1 pyrimidine utilization protein B -
OI907_RS05030 (OI907_05020) 953831..954217 + 387 WP_033145166.1 pyrimidine utilization protein C -
OI907_RS05035 (OI907_05025) 954225..955025 + 801 WP_033145165.1 pyrimidine utilization protein D -
OI907_RS05040 (OI907_05030) 955035..955625 + 591 WP_033145164.1 malonic semialdehyde reductase -
OI907_RS05045 (OI907_05035) 955635..956129 + 495 WP_032658088.1 pyrimidine utilization flavin reductase protein F -
OI907_RS05050 (OI907_05040) 956151..957473 + 1323 WP_033145163.1 pyrimidine utilization transport protein G -
OI907_RS05055 (OI907_05045) 957547..958047 - 501 WP_172421424.1 GNAT family N-acetyltransferase Toxin
OI907_RS05060 (OI907_05050) 958075..958344 - 270 WP_008499829.1 DUF1778 domain-containing protein Antitoxin
OI907_RS05065 (OI907_05055) 958406..959323 - 918 WP_033145161.1 DMT family transporter -
OI907_RS05070 (OI907_05060) 959441..959611 - 171 WP_023311077.1 general stress protein -
OI907_RS05075 (OI907_05065) 960002..960598 + 597 WP_023311076.1 NAD(P)H:quinone oxidoreductase -
OI907_RS05080 (OI907_05070) 960619..960846 + 228 WP_033145160.1 YccJ family protein -
OI907_RS05085 (OI907_05075) 960880..962121 - 1242 WP_033145159.1 bifunctional glucose-1-phosphatase/inositol phosphatase -
OI907_RS05090 (OI907_05080) 962274..962717 + 444 WP_032658095.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 18969.67 Da        Isoelectric Point: 7.9145

>T261979 WP_172421424.1 NZ_CP109692:c958047-957547 [Enterobacter asburiae]
MLSEGTDYDFEDFDCGEPSLNAFLAEHLVRQHNGRILRAYLLKERDRPRVLGYYTLSGSCFERAMLPSKTQQRRIPYINV
PSVTLGRLAVDKTLQGNEWGTTLVAHAMRVVYLASQAVGVHGIFVDALNERAKRFYLKQGFIPLTAENSHSLFFPTKSIE
RLFEQE

Download         Length: 501 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10262.72 Da        Isoelectric Point: 5.8836

>AT261979 WP_008499829.1 NZ_CP109692:c958344-958075 [Enterobacter asburiae]
MPALKKQRIDLRLTDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWNAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W7PG43

References