Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 31270..32009 Replicon plasmid p2017-45-80_2
Accession NZ_CP109691
Organism Enterobacter asburiae strain 2017-45-80

Toxin (Protein)


Gene name tacT Uniprot ID A0A9E6WPH7
Locus tag OI907_RS00200 Protein ID WP_013087269.1
Coordinates 31524..32009 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A9E6WPN8
Locus tag OI907_RS00195 Protein ID WP_007869691.1
Coordinates 31270..31536 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI907_RS00185 (OI907_00185) 26862..29759 + 2898 WP_004206881.1 Tn3-like element Tn5403 family transposase -
OI907_RS00190 (OI907_00190) 29793..30602 - 810 Protein_37 plasmid replication initiator RepA -
OI907_RS00195 (OI907_00195) 31270..31536 + 267 WP_007869691.1 DUF1778 domain-containing protein Antitoxin
OI907_RS00200 (OI907_00200) 31524..32009 + 486 WP_013087269.1 GNAT family N-acetyltransferase Toxin
OI907_RS00205 (OI907_00205) 32210..32821 - 612 WP_223998213.1 hypothetical protein -
OI907_RS00210 (OI907_00210) 32834..33244 - 411 WP_023327703.1 hypothetical protein -
OI907_RS00215 (OI907_00215) 33447..34716 - 1270 Protein_42 type II toxin-antitoxin system HipA family toxin -
OI907_RS00220 (OI907_00220) 34721..35014 - 294 WP_032636197.1 helix-turn-helix transcriptional regulator -
OI907_RS00225 (OI907_00225) 35579..36583 - 1005 WP_000427623.1 IS110-like element IS4321 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..62976 62976


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-146)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17736.45 Da        Isoelectric Point: 9.5181

>T261977 WP_013087269.1 NZ_CP109691:31524-32009 [Enterobacter asburiae]
VGRVTAPEPLSSSHQLAEFVSGEAVLDDWLKQRGLKNQALGAARTFVVCKRDTKQVVGFYSLATGSVNHVEAMGSLRRNM
PDPIPVIILARLAVDVSYRGQGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYLHHGFKASQTQERTLFLKLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10080.46 Da        Isoelectric Point: 4.3837

>AT261977 WP_007869691.1 NZ_CP109691:31270-31536 [Enterobacter asburiae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVSDEAAIDKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References