Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 4865360..4865933 Replicon chromosome
Accession NZ_CP109657
Organism Pseudomonas aeruginosa strain Zw26

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag OBG92_RS23040 Protein ID WP_264315568.1
Coordinates 4865360..4865647 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID W5ISI7
Locus tag OBG92_RS23045 Protein ID WP_009618210.1
Coordinates 4865634..4865933 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OBG92_RS23015 (OBG92_04529) 4860991..4863021 - 2031 WP_264315563.1 DNA topoisomerase III -
OBG92_RS23020 (OBG92_04530) 4863317..4863700 - 384 WP_264315564.1 single-stranded DNA-binding protein -
OBG92_RS23025 (OBG92_04531) 4863697..4864245 - 549 WP_264315565.1 DUF3158 family protein -
OBG92_RS23030 (OBG92_04532) 4864242..4865021 - 780 WP_264315566.1 TIGR03761 family integrating conjugative element protein -
OBG92_RS23035 (OBG92_04533) 4865141..4865275 - 135 WP_264315567.1 hypothetical protein -
OBG92_RS23040 (OBG92_04534) 4865360..4865647 - 288 WP_264315568.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OBG92_RS23045 (OBG92_04535) 4865634..4865933 - 300 WP_009618210.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OBG92_RS23050 (OBG92_04536) 4866061..4867254 - 1194 WP_264315569.1 STY4528 family pathogenicity island replication protein -
OBG92_RS23055 (OBG92_04537) 4867257..4867817 - 561 WP_150554693.1 DUF2857 domain-containing protein -
OBG92_RS23060 (OBG92_04538) 4867835..4869493 - 1659 WP_264315570.1 ParB family protein -
OBG92_RS23065 (OBG92_04539) 4869486..4869734 - 249 WP_264315571.1 type II toxin-antitoxin system HicA family toxin -
OBG92_RS23070 (OBG92_04540) 4869718..4870584 - 867 WP_264315572.1 ParA family protein -
OBG92_RS23075 (OBG92_04541) 4870626..4870844 - 219 WP_009461157.1 AlpA family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-58)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10824.37 Da        Isoelectric Point: 8.4628

>T261974 WP_264315568.1 NZ_CP109657:c4865647-4865360 [Pseudomonas aeruginosa]
VRVLEWREAARADLLAIVDYISDDNPDAAQRLKDDIEAKAAKLPERPKLYRPGRVAGTREMVVRSNYVVVYVEDSRAVSI
LRVLHAAQQWPPARE

Download         Length: 288 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10816.46 Da        Isoelectric Point: 8.6579

>AT261974 WP_009618210.1 NZ_CP109657:c4865933-4865634 [Pseudomonas aeruginosa]
MAAQTSMLHIRVDDKLKADAAEKLAGVGLTVSDAVRILLTRVVKEGALPAGLTADPEAYDAWFRAKVQEALADTRPPVPH
QQVMDEAQALIDRKRRART

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5R9QE11

References