Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4376281..4377541 Replicon chromosome
Accession NZ_CP109657
Organism Pseudomonas aeruginosa strain Zw26

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag OBG92_RS20465 Protein ID WP_079384946.1
Coordinates 4376281..4377036 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A2R3IR82
Locus tag OBG92_RS20470 Protein ID WP_003157715.1
Coordinates 4377173..4377541 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OBG92_RS20450 4373063..4373446 + 384 WP_264315467.1 penicillin acylase family protein -
OBG92_RS20455 (OBG92_04031) 4373595..4374146 + 552 WP_264315468.1 AAA family ATPase -
OBG92_RS20460 (OBG92_04032) 4374150..4375511 - 1362 WP_079383456.1 DNA recombination protein RmuC -
OBG92_RS20465 (OBG92_04033) 4376281..4377036 - 756 WP_079384946.1 RES family NAD+ phosphorylase Toxin
OBG92_RS20470 (OBG92_04034) 4377173..4377541 - 369 WP_003157715.1 DUF2384 domain-containing protein Antitoxin
OBG92_RS20475 (OBG92_04035) 4377615..4378901 - 1287 WP_058129151.1 FAD-binding oxidoreductase -
OBG92_RS20480 (OBG92_04036) 4378965..4380556 - 1592 Protein_4055 aldehyde dehydrogenase family protein -
OBG92_RS20485 (OBG92_04037) 4380632..4381108 + 477 WP_034079587.1 elongation factor GreAB -
OBG92_RS20490 (OBG92_04038) 4381111..4381392 - 282 WP_034079448.1 zinc ribbon domain-containing protein -
OBG92_RS20495 (OBG92_04039) 4381545..4382531 - 987 WP_079977066.1 NADH:ubiquinone reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(64-205)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(8-67)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28310.55 Da        Isoelectric Point: 8.3280

>T261972 WP_079384946.1 NZ_CP109657:c4377036-4376281 [Pseudomonas aeruginosa]
VSEIWRLCAGEKQVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPLPESAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPGLFYAALKLETAMAEGAYYRCVLWSGMAVPPPSGRILSEHASFEAAWKVERGVRLQEPPFSDYERALTDTA
DYRVAQELGSAMRGAGVQAFEYRSARCPQRGCNVALFTPRAFIEKRPRNLTPWLCETTASYVAFKPAHVPGSPKVFAREL
FLVDGRLPLPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13353.60 Da        Isoelectric Point: 9.9874

>AT261972 WP_003157715.1 NZ_CP109657:c4377541-4377173 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGILGVDRSAISRWKSQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDLRHFMRTPNHHLGGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2R3IR82

References