Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicB(antitoxin) |
| Location | 2573478..2574406 | Replicon | chromosome |
| Accession | NZ_CP109657 | ||
| Organism | Pseudomonas aeruginosa strain Zw26 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | OBG92_RS12215 | Protein ID | WP_192223567.1 |
| Coordinates | 2574227..2574406 (-) | Length | 60 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | OBG92_RS12210 | Protein ID | WP_128671008.1 |
| Coordinates | 2573478..2574173 (-) | Length | 232 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OBG92_RS12185 | 2569335..2569553 | + | 219 | WP_003451709.1 | Cro/CI family transcriptional regulator | - |
| OBG92_RS12190 (OBG92_02408) | 2569585..2570175 | + | 591 | WP_264315864.1 | hypothetical protein | - |
| OBG92_RS12195 (OBG92_02409) | 2570486..2572036 | + | 1551 | WP_264315865.1 | replication protein P | - |
| OBG92_RS12200 (OBG92_02410) | 2572029..2572478 | + | 450 | WP_264315866.1 | RusA family crossover junction endodeoxyribonuclease | - |
| OBG92_RS12205 (OBG92_02411) | 2572507..2573376 | + | 870 | WP_264315867.1 | hypothetical protein | - |
| OBG92_RS12210 (OBG92_02412) | 2573478..2574173 | - | 696 | WP_128671008.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| OBG92_RS12215 (OBG92_02413) | 2574227..2574406 | - | 180 | WP_192223567.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| OBG92_RS12220 (OBG92_02414) | 2574491..2574799 | + | 309 | WP_012075324.1 | hypothetical protein | - |
| OBG92_RS12225 (OBG92_02415) | 2574802..2575092 | + | 291 | WP_264315868.1 | hypothetical protein | - |
| OBG92_RS12230 (OBG92_02416) | 2575156..2575341 | + | 186 | WP_264315869.1 | YodC family protein | - |
| OBG92_RS12235 (OBG92_02417) | 2575401..2575982 | + | 582 | WP_264315870.1 | terminase small subunit | - |
| OBG92_RS12240 (OBG92_02418) | 2575979..2577304 | + | 1326 | WP_264315871.1 | terminase family protein | - |
| OBG92_RS12245 (OBG92_02419) | 2577307..2578662 | + | 1356 | WP_264315872.1 | DUF4055 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2541841..2603772 | 61931 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 60 a.a. Molecular weight: 6600.67 Da Isoelectric Point: 11.0007
>T261970 WP_192223567.1 NZ_CP109657:c2574406-2574227 [Pseudomonas aeruginosa]
MKFSEFRRWLKAHGVTFEAGKGSHFKITAPNGKTTTFADHGAKEMPEPTRKAIIKQLGL
MKFSEFRRWLKAHGVTFEAGKGSHFKITAPNGKTTTFADHGAKEMPEPTRKAIIKQLGL
Download Length: 180 bp
Antitoxin
Download Length: 232 a.a. Molecular weight: 26190.70 Da Isoelectric Point: 4.7290
>AT261970 WP_128671008.1 NZ_CP109657:c2574173-2573478 [Pseudomonas aeruginosa]
MYDYAIRFEQDDSAPGVAVFCRDLPELNSFGDDREHAIREALDAIETTLSLYVDARKPIPEATAPEEGEHVVHLPAVTVA
KIALWNEMMKRGMRKSDLCKLLGIAQTQGDRLVDFLHNTKMEALEQALAALDTKLSVRTYYGNQMVKLRYIANMERGRVL
VIAGDADPKALPRQYEWLQEPPCRIEDTVDDFEVGARYAMWNVEEAVNSIQSRGYFSFWLETTSGPRSASR
MYDYAIRFEQDDSAPGVAVFCRDLPELNSFGDDREHAIREALDAIETTLSLYVDARKPIPEATAPEEGEHVVHLPAVTVA
KIALWNEMMKRGMRKSDLCKLLGIAQTQGDRLVDFLHNTKMEALEQALAALDTKLSVRTYYGNQMVKLRYIANMERGRVL
VIAGDADPKALPRQYEWLQEPPCRIEDTVDDFEVGARYAMWNVEEAVNSIQSRGYFSFWLETTSGPRSASR
Download Length: 696 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|