Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1807758..1809266 Replicon chromosome
Accession NZ_CP109657
Organism Pseudomonas aeruginosa strain Zw26

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag OBG92_RS08455 Protein ID WP_079383582.1
Coordinates 1807758..1808345 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A2R3IYR9
Locus tag OBG92_RS08460 Protein ID WP_043100748.1
Coordinates 1808412..1809266 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OBG92_RS08450 (OBG92_01671) 1804013..1807492 - 3480 WP_256157413.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
OBG92_RS08455 (OBG92_01672) 1807758..1808345 + 588 WP_079383582.1 GNAT family protein Toxin
OBG92_RS08460 (OBG92_01673) 1808412..1809266 + 855 WP_043100748.1 AraC family transcriptional regulator Antitoxin
OBG92_RS08465 (OBG92_01674) 1809362..1811527 + 2166 WP_256157417.1 TonB-dependent receptor family protein -
OBG92_RS08470 (OBG92_01675) 1811702..1813576 + 1875 WP_256157419.1 MFS transporter -
OBG92_RS08475 (OBG92_01676) 1813637..1813846 - 210 WP_003091604.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-147)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21862.19 Da        Isoelectric Point: 9.8675

>T261969 WP_079383582.1 NZ_CP109657:1807758-1808345 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQGIADQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQFSTAASNLRAQGAIDKLGAQREGLLRN
QRRLAGGRLDDTIVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31716.04 Da        Isoelectric Point: 8.0066

>AT261969 WP_043100748.1 NZ_CP109657:1808412-1809266 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAALGGVELLHARYVEQRFAPHVHSGFALVFIEQGAQRFRHRGGEHLAPWGSMVLINPDEVHTGSK
AHDSGWLYRGYYPEVEQIASVLDELEIRHGGVPRFADSVVHDQPLARAFVHLHRLLADHAGSLETQTCWRETLLALFRRH
ARLPEAPKAGSEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKNGRA
PLDVALELGFADQSHLGRQFKQAYGVAPGEYRAACARSSLTMCE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2R3IYR9

References