Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 607266..607880 Replicon chromosome
Accession NZ_CP109657
Organism Pseudomonas aeruginosa strain Zw26

Toxin (Protein)


Gene name hicA Uniprot ID A6VBH9
Locus tag OBG92_RS02860 Protein ID WP_071534354.1
Coordinates 607266..607448 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A140SDX7
Locus tag OBG92_RS02865 Protein ID WP_012077229.1
Coordinates 607476..607880 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OBG92_RS02845 (OBG92_00557) 603870..604748 - 879 Protein_567 IS3 family transposase -
OBG92_RS02850 (OBG92_00558) 604758..606107 - 1350 WP_058146648.1 IS110 family transposase -
OBG92_RS02855 (OBG92_00559) 606332..606580 - 249 Protein_569 transposase -
OBG92_RS02860 (OBG92_00560) 607266..607448 + 183 WP_071534354.1 type II toxin-antitoxin system HicA family toxin Toxin
OBG92_RS02865 (OBG92_00561) 607476..607880 + 405 WP_012077229.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OBG92_RS02870 (OBG92_00562) 607923..608894 - 972 WP_012077228.1 hypothetical protein -
OBG92_RS02875 (OBG92_00563) 608879..609577 - 699 WP_033896049.1 hypothetical protein -
OBG92_RS02880 (OBG92_00564) 609577..610116 - 540 WP_012074127.1 hypothetical protein -
OBG92_RS02885 (OBG92_00565) 610113..611033 - 921 WP_012074128.1 hypothetical protein -
OBG92_RS02890 (OBG92_00566) 611030..611740 - 711 WP_012074129.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lpg2359 599400..654775 55375
- flank IS/Tn - - 603870..604724 854


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6702.74 Da        Isoelectric Point: 10.4826

>T261968 WP_071534354.1 NZ_CP109657:607266-607448 [Pseudomonas aeruginosa]
MRSREVIDLLLEDGWYEVAVKGSHHQFKHPSKPGKVTVQHPSSTIPKGTLNNILKQAGLK

Download         Length: 183 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14670.54 Da        Isoelectric Point: 4.4315

>AT261968 WP_012077229.1 NZ_CP109657:607476-607880 [Pseudomonas aeruginosa]
MKFPVVLHKDPDSDYGVTVPDVPGCFSAGATVSEALANVEEALALHFEGLVTDGEELPQPQDVDAHMKNPDFEGGVWAVV
DFDVTPYLGKAVRFNATLPEHLLQRIDERVKVDKRYQSRSGFLATAAMRELSVA

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6VBH9

Antitoxin

Source ID Structure
AlphaFold DB A0A140SDX7

References