261967

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 138851..139356 Replicon chromosome
Accession NZ_CP109657
Organism Pseudomonas aeruginosa strain Zw26

Toxin (Protein)


Gene name parE Uniprot ID A0A2R3IRV5
Locus tag OBG92_RS00645 Protein ID WP_058145534.1
Coordinates 138851..139132 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A4P0TKN5
Locus tag OBG92_RS00650 Protein ID WP_034081045.1
Coordinates 139129..139356 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OBG92_RS00620 (OBG92_00121) 134110..135459 + 1350 WP_023443219.1 C4-dicarboxylate transporter DctA -
OBG92_RS00625 (OBG92_00122) 135507..136193 + 687 WP_011979163.1 FadR/GntR family transcriptional regulator -
OBG92_RS00630 (OBG92_00123) 136294..137028 + 735 WP_058145532.1 GntR family transcriptional regulator -
OBG92_RS00635 (OBG92_00124) 137207..137596 + 390 WP_235582454.1 aegerolysin family protein -
OBG92_RS00640 (OBG92_00125) 137663..138553 - 891 WP_043099741.1 LysR family transcriptional regulator -
OBG92_RS00645 (OBG92_00126) 138851..139132 - 282 WP_058145534.1 type II toxin-antitoxin system toxin ParE Toxin
OBG92_RS00650 (OBG92_00127) 139129..139356 - 228 WP_034081045.1 CopG family ribbon-helix-helix protein Antitoxin
OBG92_RS00655 (OBG92_00128) 139532..140152 - 621 WP_058145551.1 hypothetical protein -
OBG92_RS00660 (OBG92_00129) 140253..140753 + 501 WP_034081042.1 LEA type 2 family protein -
OBG92_RS00665 (OBG92_00130) 140826..141167 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
OBG92_RS00670 (OBG92_00131) 141287..142714 - 1428 WP_058135775.1 GABA permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10419.13 Da        Isoelectric Point: 9.6558

>T261967 WP_058145534.1 NZ_CP109657:c139132-138851 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDVVEQVKPLQEVANQGAGRPSEVPGVRTLALERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT261967 WP_034081045.1 NZ_CP109657:c139356-139129 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHLEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R3IRV5

Antitoxin

Source ID Structure
AlphaFold DB A0A4P0TKN5

References