Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 522130..522766 Replicon chromosome
Accession NZ_CP109651
Organism Bacillus safensis strain LG01

Toxin (Protein)


Gene name mazF Uniprot ID A0A0P7G713
Locus tag N8A73_RS02520 Protein ID WP_024425388.1
Coordinates 522416..522766 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W8QJ31
Locus tag N8A73_RS02515 Protein ID WP_003214273.1
Coordinates 522130..522411 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8A73_RS02495 518284..518889 - 606 WP_041116754.1 rhomboid family intramembrane serine protease -
N8A73_RS02500 518984..519349 + 366 WP_041116756.1 holo-ACP synthase -
N8A73_RS02505 519510..520526 + 1017 WP_098677666.1 outer membrane lipoprotein-sorting protein -
N8A73_RS02510 520654..521835 + 1182 WP_061110629.1 alanine racemase -
N8A73_RS02515 522130..522411 + 282 WP_003214273.1 hypothetical protein Antitoxin
N8A73_RS02520 522416..522766 + 351 WP_024425388.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
N8A73_RS02525 522882..523712 + 831 WP_034283948.1 RsbT co-antagonist protein RsbRA -
N8A73_RS02530 523717..524085 + 369 WP_003214235.1 RsbT antagonist protein RsbS -
N8A73_RS02535 524088..524489 + 402 WP_024427376.1 anti-sigma regulatory factor -
N8A73_RS02540 524500..525507 + 1008 WP_024427377.1 PP2C family protein-serine/threonine phosphatase -
N8A73_RS02545 525567..525896 + 330 WP_024425392.1 anti-sigma factor antagonist -
N8A73_RS02550 525893..526381 + 489 WP_034283945.1 anti-sigma B factor RsbW -
N8A73_RS02555 526347..527135 + 789 WP_024427378.1 RNA polymerase sigma factor SigB -
N8A73_RS02560 527135..527734 + 600 WP_176967302.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8891

>T261965 WP_024425388.1 NZ_CP109651:522416-522766 [Bacillus safensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10864.25 Da        Isoelectric Point: 5.2726

>AT261965 WP_003214273.1 NZ_CP109651:522130-522411 [Bacillus safensis]
MSESSATNEMKIRLPEALMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P7G713

Antitoxin

Source ID Structure
AlphaFold DB A0A081L854

References