Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 2367847..2368397 Replicon chromosome
Accession NZ_CP109619
Organism Treponema denticola strain KCOM 3500

Toxin (Protein)


Gene name relE Uniprot ID Q73QD8
Locus tag OE909_RS11030 Protein ID WP_002665928.1
Coordinates 2368116..2368397 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q73QD7
Locus tag OE909_RS11025 Protein ID WP_002665927.1
Coordinates 2367847..2368119 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OE909_RS10990 (OE909_10990) 2363803..2364126 + 324 WP_002681645.1 hypothetical protein -
OE909_RS10995 (OE909_10995) 2364233..2365027 + 795 WP_002665906.1 DUF4261 domain-containing protein -
OE909_RS11000 (OE909_11000) 2365104..2365262 + 159 WP_010956759.1 hypothetical protein -
OE909_RS11005 (OE909_11005) 2365464..2366135 + 672 WP_264306752.1 hypothetical protein -
OE909_RS11010 (OE909_11010) 2366191..2366760 + 570 WP_253704009.1 hypothetical protein -
OE909_RS11015 (OE909_11015) 2366805..2367521 + 717 WP_253682847.1 hypothetical protein -
OE909_RS11020 (OE909_11020) 2367572..2367781 + 210 WP_002687090.1 hypothetical protein -
OE909_RS11025 (OE909_11025) 2367847..2368119 + 273 WP_002665927.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OE909_RS11030 (OE909_11030) 2368116..2368397 + 282 WP_002665928.1 type II toxin-antitoxin system YafQ family toxin Toxin
OE909_RS11035 (OE909_11035) 2368460..2369095 + 636 WP_002685240.1 hypothetical protein -
OE909_RS11040 (OE909_11040) 2369133..2369984 + 852 WP_264306753.1 DUF2262 domain-containing protein -
OE909_RS11045 (OE909_11045) 2370021..2370782 + 762 WP_264306754.1 class I SAM-dependent methyltransferase -
OE909_RS11050 (OE909_11050) 2370971..2371861 + 891 WP_264306755.1 IS5 family transposase -
OE909_RS11055 (OE909_11055) 2372281..2372940 + 660 WP_253677615.1 hypothetical protein -
OE909_RS11060 (OE909_11060) 2372988..2373131 + 144 WP_002672584.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-89)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11113.98 Da        Isoelectric Point: 9.8023

>T261963 WP_002665928.1 NZ_CP109619:2368116-2368397 [Treponema denticola]
MKYEIKFTNQFKKDIKLAKKQNKNLDKLLKVIDLLSNGEKLEAKYRDHDLSGNYKGTRECHIEPDWLLVYEIRNDVLVLM
LYRLGSHSELFKK

Download         Length: 282 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10205.78 Da        Isoelectric Point: 5.1486

>AT261963 WP_002665927.1 NZ_CP109619:2367847-2368119 [Treponema denticola]
MATTNLNIRTDKEMKERAEAIFFELGLNMTTAINIFLRTTIRENGIPFALKLDIPNAITASAIEEGRKIAYDDTVKKYSN
IDDLRKALEI

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q73QD8

Antitoxin

Source ID Structure
AlphaFold DB Q73QD7

References