261961

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 4601..5157 Replicon chromosome
Accession NZ_CP109619
Organism Treponema denticola strain KCOM 3500

Toxin (Protein)


Gene name relE Uniprot ID Q73QZ0
Locus tag OE909_RS00030 Protein ID WP_002676650.1
Coordinates 4876..5157 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q73QZ1
Locus tag OE909_RS00025 Protein ID WP_002676649.1
Coordinates 4601..4879 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OE909_RS00010 (OE909_00010) 1126..2025 - 900 WP_002666354.1 glutamate formimidoyltransferase -
OE909_RS00015 (OE909_00015) 2221..3651 + 1431 WP_264306957.1 leucyl aminopeptidase -
OE909_RS00020 (OE909_00020) 3725..4528 + 804 WP_253681138.1 class I SAM-dependent methyltransferase -
OE909_RS00025 (OE909_00025) 4601..4879 + 279 WP_002676649.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OE909_RS00030 (OE909_00030) 4876..5157 + 282 WP_002676650.1 type II toxin-antitoxin system YafQ family toxin Toxin
OE909_RS00035 (OE909_00035) 5234..6790 + 1557 WP_264306958.1 hypothetical protein -
OE909_RS00040 (OE909_00040) 6974..8080 - 1107 WP_264306959.1 redox-regulated ATPase YchF -
OE909_RS00045 (OE909_00045) 8105..9934 - 1830 WP_264306960.1 signal peptide peptidase SppA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-70)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10774.68 Da        Isoelectric Point: 10.2467

>T261961 WP_002676650.1 NZ_CP109619:4876-5157 [Treponema denticola]
MIYQLKKTSQFKASVKLAKKRGLNINLLEGIIEKLRTDTPLGVKHKNHQLSGQFKGIWECHIQPDWLLLYLKEENNLVMT
LVDTGTHSDIFKK

Download         Length: 282 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10223.83 Da        Isoelectric Point: 6.2705

>AT261961 WP_002676649.1 NZ_CP109619:4601-4879 [Treponema denticola]
MSTAVLQTRVDSQIKKEADDLFNALGIDTTTAIRLFLKQAINQQKIPFEILPPQKEFSPSVLAAIKEARQISCDASVKQY
KTAKELLADCEV

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q73QZ0

Antitoxin

Source ID Structure
AlphaFold DB Q73QZ1

References