Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 4828917..4830598 | Replicon | chromosome |
| Accession | NZ_CP109614 | ||
| Organism | Klebsiella sp. KP20-425-1 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | A6TH06 |
| Locus tag | OHJ17_RS23595 | Protein ID | WP_015959269.1 |
| Coordinates | 4828917..4829792 (-) | Length | 292 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | A6TH05 |
| Locus tag | OHJ17_RS23600 | Protein ID | WP_004177809.1 |
| Coordinates | 4829840..4830598 (-) | Length | 253 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OHJ17_RS23575 (4824223) | 4824223..4825743 | + | 1521 | WP_002885173.1 | sugar ABC transporter ATP-binding protein | - |
| OHJ17_RS23580 (4825740) | 4825740..4826738 | + | 999 | WP_002885172.1 | ribose ABC transporter permease | - |
| OHJ17_RS23585 (4826769) | 4826769..4827710 | + | 942 | WP_002885156.1 | ABC transporter substrate-binding protein | - |
| OHJ17_RS23590 (4827785) | 4827785..4828792 | + | 1008 | WP_015959270.1 | carbohydrate kinase family protein | - |
| OHJ17_RS23595 (4828917) | 4828917..4829792 | - | 876 | WP_015959269.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| OHJ17_RS23600 (4829840) | 4829840..4830598 | - | 759 | WP_004177809.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| OHJ17_RS23605 (4830684) | 4830684..4831412 | - | 729 | WP_032413197.1 | response regulator transcription factor | - |
| OHJ17_RS23610 (4831685) | 4831685..4833832 | + | 2148 | WP_012737173.1 | formate dehydrogenase H subunit alpha, selenocysteine-containing | - |
| OHJ17_RS23615 (4834294) | 4834294..4834980 | + | 687 | WP_004151733.1 | tetratricopeptide repeat protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 292 a.a. Molecular weight: 32990.17 Da Isoelectric Point: 5.4637
>T261957 WP_015959269.1 NZ_CP109614:c4829792-4828917 [Klebsiella sp. KP20-425-1]
MQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQAGMSAVLQANRSDE
MRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQHPRDFYDVKLLLDAQ
ELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKSCITQQDVDFLLSFK
RGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
MQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQAGMSAVLQANRSDE
MRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQHPRDFYDVKLLLDAQ
ELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKSCITQQDVDFLLSFK
RGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
Download Length: 876 bp
Antitoxin
Download Length: 253 a.a. Molecular weight: 28548.92 Da Isoelectric Point: 10.0870
>AT261957 WP_004177809.1 NZ_CP109614:c4830598-4829840 [Klebsiella sp. KP20-425-1]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
Download Length: 759 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|