Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4669178..4669694 Replicon chromosome
Accession NZ_CP109614
Organism Klebsiella sp. KP20-425-1

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag OHJ17_RS22780 Protein ID WP_009486548.1
Coordinates 4669178..4669462 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag OHJ17_RS22785 Protein ID WP_002886901.1
Coordinates 4669452..4669694 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OHJ17_RS22755 (4664595) 4664595..4664858 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
OHJ17_RS22760 (4664988) 4664988..4665161 + 174 WP_032433782.1 hypothetical protein -
OHJ17_RS22765 (4665164) 4665164..4665907 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
OHJ17_RS22770 (4666264) 4666264..4668402 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
OHJ17_RS22775 (4668710) 4668710..4669174 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OHJ17_RS22780 (4669178) 4669178..4669462 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OHJ17_RS22785 (4669452) 4669452..4669694 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OHJ17_RS22790 (4669772) 4669772..4671682 - 1911 WP_009486549.1 PRD domain-containing protein -
OHJ17_RS22795 (4671705) 4671705..4672859 - 1155 WP_002886900.1 lactonase family protein -
OHJ17_RS22800 (4672926) 4672926..4673666 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T261956 WP_009486548.1 NZ_CP109614:c4669462-4669178 [Klebsiella sp. KP20-425-1]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT261956 WP_002886901.1 NZ_CP109614:c4669694-4669452 [Klebsiella sp. KP20-425-1]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References