Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/Txe-RelB
Location 843468..843975 Replicon chromosome
Accession NC_017043
Organism Rickettsia montanensis str. OSU 85-930

Toxin (Protein)


Gene name relB Uniprot ID H8KBS2
Locus tag MCI_RS04630 Protein ID WP_014409861.1
Coordinates 843468..843731 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID H8K421
Locus tag MCI_RS04635 Protein ID WP_014391803.1
Coordinates 843724..843975 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MCI_RS09065 838992..839378 + 387 Protein_946 hypothetical protein -
MCI_RS09070 839511..840008 + 498 WP_198002889.1 Sca4 family protein -
MCI_RS04615 840029..841399 - 1371 WP_014409858.1 lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase -
MCI_RS04620 841396..842052 - 657 WP_014409859.1 lysophospholipid acyltransferase family protein -
MCI_RS04625 842203..843408 - 1206 WP_014409860.1 pyridoxal phosphate-dependent aminotransferase -
MCI_RS04630 843468..843731 - 264 WP_014409861.1 Txe/YoeB family addiction module toxin Toxin
MCI_RS04635 843724..843975 - 252 WP_014391803.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MCI_RS04640 844115..845119 + 1005 WP_014409862.1 methyltransferase domain-containing protein -
MCI_RS04645 845124..845879 + 756 WP_041404235.1 VacJ family lipoprotein -
MCI_RS04650 845899..846498 + 600 WP_014409864.1 phospholipid-binding protein MlaC -
MCI_RS07860 846723..847722 + 1000 Protein_956 ribose-phosphate diphosphokinase -
MCI_RS04670 847719..848786 + 1068 WP_014409865.1 alanine racemase -
MCI_RS08585 848687..848920 - 234 WP_156794997.1 palindromic element RPE4 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10537.36 Da        Isoelectric Point: 9.3551

>T26195 WP_014409861.1 NC_017043:c843731-843468 [Rickettsia montanensis str. OSU 85-930]
MIEIEWTLEAAEDLAYWKKYDIKKYECIKLLIKNIQEAPFTGIGKPEPLKHMLSGLWSRRINHEHRLIYSVNTKQIIIYN
CRFHYKN

Download         Length: 264 bp

>T26195 NC_017043:c843731-843468 [Rickettsia montanensis str. OSU 85-930]
ATGATTGAGATTGAGTGGACACTAGAAGCAGCGGAGGATTTAGCGTATTGGAAAAAATACGATATTAAAAAATATGAATG
TATTAAACTTCTAATAAAAAATATCCAAGAAGCACCATTTACAGGTATAGGTAAGCCCGAACCTTTAAAACATATGTTAT
CAGGTTTATGGTCACGTAGAATTAACCACGAACATAGACTAATATATTCTGTCAATACTAAACAAATTATAATATATAAT
TGTAGATTTCATTATAAAAATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9521.77 Da        Isoelectric Point: 9.4884

>AT26195 WP_014391803.1 NC_017043:c843975-843724 [Rickettsia montanensis str. OSU 85-930]
MNSISGTSFRKNLSSVLNTVENDHVPYLIKRKNHKNIILLTEEEYESTKETLYLLSNPANANRIKKSIEQAKRGEFAKVN
LDD

Download         Length: 252 bp

>AT26195 NC_017043:c843975-843724 [Rickettsia montanensis str. OSU 85-930]
ATGAACTCAATTAGCGGCACTTCATTTAGAAAAAACTTAAGCTCTGTACTAAATACCGTAGAAAACGATCATGTCCCTTA
TCTTATTAAAAGAAAGAATCATAAGAATATTATTCTTTTAACCGAAGAAGAATATGAATCTACAAAAGAAACATTATATT
TATTATCTAATCCAGCTAATGCGAATCGAATAAAAAAATCTATTGAACAAGCAAAAAGAGGAGAGTTTGCTAAAGTTAAT
TTAGATGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H8KBS2

Antitoxin

Source ID Structure
AlphaFold DB A0A0C2M0P5

References