Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1450035..1450678 Replicon chromosome
Accession NZ_CP109614
Organism Klebsiella sp. KP20-425-1

Toxin (Protein)


Gene name vagD Uniprot ID A0A4S8C081
Locus tag OHJ17_RS07165 Protein ID WP_032433387.1
Coordinates 1450262..1450678 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag OHJ17_RS07160 Protein ID WP_001261276.1
Coordinates 1450035..1450265 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OHJ17_RS07145 (1445057) 1445057..1446144 + 1088 Protein_1394 transcriptional regulator -
OHJ17_RS07150 (1446147) 1446147..1448387 + 2241 WP_045326788.1 P-loop NTPase fold protein -
OHJ17_RS07155 (1448915) 1448915..1449730 - 816 WP_032433388.1 hypothetical protein -
OHJ17_RS07160 (1450035) 1450035..1450265 + 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
OHJ17_RS07165 (1450262) 1450262..1450678 + 417 WP_032433387.1 type II toxin-antitoxin system VapC family toxin Toxin
OHJ17_RS07170 (1450834) 1450834..1451814 + 981 WP_032433385.1 hypothetical protein -
OHJ17_RS07175 (1452009) 1452009..1453580 - 1572 WP_032433383.1 AAA family ATPase -
OHJ17_RS07180 (1453899) 1453899..1454147 + 249 WP_032433382.1 hypothetical protein -
OHJ17_RS07185 (1454206) 1454206..1454724 + 519 WP_045326794.1 hypothetical protein -
OHJ17_RS07190 (1454755) 1454755..1455246 + 492 WP_032433378.1 hypothetical protein -
OHJ17_RS07195 (1455306) 1455306..1455509 + 204 WP_032433376.1 HHA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1434671..1480170 45499


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14974.43 Da        Isoelectric Point: 7.8921

>T261947 WP_032433387.1 NZ_CP109614:1450262-1450678 [Klebsiella sp. KP20-425-1]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALHLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLTLEDWVI

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT261947 WP_001261276.1 NZ_CP109614:1450035-1450265 [Klebsiella sp. KP20-425-1]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S8C081

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References