261943

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 47127..48264 Replicon plasmid pAFL-109F
Accession NZ_CP109613
Organism Enterococcus faecalis strain AFL-109F

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag OGM83_RS14105 Protein ID WP_283658642.1
Coordinates 47127..47990 (-) Length 288 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID B3CKC7
Locus tag OGM83_RS14110 Protein ID WP_002333002.1
Coordinates 47992..48264 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OGM83_RS14080 (42402) 42402..42926 + 525 WP_010717848.1 IS30 family transposase -
OGM83_RS14085 (42998) 42998..44611 - 1614 WP_002333004.1 hypothetical protein -
OGM83_RS14090 (44635) 44635..45516 - 882 WP_002326774.1 ABC transporter ATP-binding protein -
OGM83_RS14095 (45827) 45827..46423 + 597 WP_002326773.1 TetR/AcrR family transcriptional regulator -
OGM83_RS14100 (46592) 46592..46996 - 405 Protein_51 DnaJ domain-containing protein -
OGM83_RS14105 (47127) 47127..47990 - 864 WP_283658642.1 zeta toxin family protein Toxin
OGM83_RS14110 (47992) 47992..48264 - 273 WP_002333002.1 antitoxin Antitoxin
OGM83_RS14115 (48282) 48282..48497 - 216 WP_001835296.1 peptide-binding protein -
OGM83_RS14120 (48589) 48589..49485 - 897 WP_104681373.1 ParA family protein -
OGM83_RS14125 (49588) 49588..51423 - 1836 WP_232035937.1 type IA DNA topoisomerase -
OGM83_RS14130 (51641) 51641..51871 + 231 WP_181039775.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid erm(A) / optrA / fexA / dfrG / aph(3')-III / erm(B) prgB/asc10 1..74497 74497


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-213)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 32391.84 Da        Isoelectric Point: 6.3643

>T261943 WP_283658642.1 NZ_CP109613:c47990-47127 [Enterococcus faecalis]
MANIVNFTDKQFENRLNDNLEELVQGKKAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVVVIDNDTFKQQHPNFDELV
KLYEKDVVKHATPYSNRMTEALISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKTYAMAVPKIESYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYLSLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMVQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGI

Download         Length: 864 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.29 Da        Isoelectric Point: 7.1987

>AT261943 WP_002333002.1 NZ_CP109613:c48264-47992 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELKAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2Z6BWJ3

References