Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2673830..2674401 Replicon chromosome
Accession NZ_CP109611
Organism Enterococcus faecalis strain AFL-109F

Toxin (Protein)


Gene name mazF Uniprot ID R3GRA7
Locus tag OGM83_RS12990 Protein ID WP_002360937.1
Coordinates 2673830..2674171 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S4CGQ1
Locus tag OGM83_RS12995 Protein ID WP_002367500.1
Coordinates 2674171..2674401 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OGM83_RS12985 (2669694) 2669694..2673308 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
OGM83_RS12990 (2673830) 2673830..2674171 - 342 WP_002360937.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OGM83_RS12995 (2674171) 2674171..2674401 - 231 WP_002367500.1 hypothetical protein Antitoxin
OGM83_RS13000 (2674724) 2674724..2674939 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
OGM83_RS13005 (2675078) 2675078..2676070 + 993 WP_192177101.1 biotin--[acetyl-CoA-carboxylase] ligase -
OGM83_RS13010 (2676160) 2676160..2676759 - 600 WP_225560887.1 RloB family protein -
OGM83_RS13015 (2676768) 2676768..2678063 - 1296 WP_192177102.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13165.41 Da        Isoelectric Point: 9.3988

>T261935 WP_002360937.1 NZ_CP109611:c2674171-2673830 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETHGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8704.69 Da        Isoelectric Point: 4.3313

>AT261935 WP_002367500.1 NZ_CP109611:c2674401-2674171 [Enterococcus faecalis]
MLTTKSRRQGNSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2A7G9

Antitoxin

Source ID Structure
AlphaFold DB S4CGQ1

References