Detailed information of TA system TA026193

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1699167..1699653
• Replicon: chromosome
• Accession: NC_017040
• Organism: Streptococcus pyogenes MGAS15252

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q48QR0
• Locus tag: MGAS15252_RS08195
• Protein ID: WP_014407961.1
• Coordinates: 1699167..1699436 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A660A1J7
• Locus tag: MGAS15252_RS08200
• Protein ID: WP_014407962.1
• Coordinates: 1699426..1699653 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MGAS15252_RS08180	1694685..1695758	+	1074	WP_002991400.1	DUF4097 family beta strand repeat protein	-
MGAS15252_RS08185	1695873..1698125	-	2253	WP_014407960.1	YhgE/Pip domain-containing protein	-
MGAS15252_RS08190	1698260..1698793	+	534	WP_002982093.1	TetR/AcrR family transcriptional regulator	-
MGAS15252_RS08195	1699167..1699436	-	270	WP_014407961.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MGAS15252_RS08200	1699426..1699653	-	228	WP_014407962.1	hypothetical protein	Antitoxin
MGAS15252_RS08205	1699806..1700177	-	372	WP_011285302.1	DUF1492 domain-containing protein	-
MGAS15252_RS08210	1700167..1700514	-	348	WP_011285303.1	DUF1492 domain-containing protein	-
MGAS15252_RS08215	1700795..1701040	-	246	WP_011285304.1	hypothetical protein	-
MGAS15252_RS08220	1701015..1701290	-	276	WP_014407964.1	hypothetical protein	-
MGAS15252_RS08225	1701280..1701618	-	339	WP_030126557.1	replication protein	-
MGAS15252_RS08230	1701660..1701926	-	267	WP_011285307.1	hypothetical protein	-
MGAS15252_RS08235	1701923..1702711	-	789	WP_011285308.1	hypothetical protein	-
MGAS15252_RS09120	1702802..1702960	-	159	WP_011285309.1	hypothetical protein	-
MGAS15252_RS08245	1702974..1703219	-	246	WP_011285310.1	hypothetical protein	-
MGAS15252_RS08250	1703215..1703541	-	327	Protein_1567	hypothetical protein	-
MGAS15252_RS09125	1703543..1703716	-	174	WP_011285312.1	hypothetical protein	-
MGAS15252_RS08935	1703722..1703895	-	174	WP_000694580.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-87)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10497.50 Da
• Isoelectric Point: 10.5027

>T26193 WP_014407961.1 NC_017040:c1699436-1699167 [Streptococcus pyogenes MGAS15252]
MTYKLVVSDEVKKQLKKMDKHVGLMLAKDMKKRLDGLNNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIILALEV
GHRKEIYKR

Nucleotide

• Length: 270 bp

>T26193 NC_017040:c1699436-1699167 [Streptococcus pyogenes MGAS15252]
ATGACTTATAAGCTAGTGGTGAGTGATGAAGTCAAGAAGCAACTCAAAAAGATGGATAAACATGTAGGGCTTATGTTAGC
CAAAGACATGAAGAAACGACTTGACGGGTTAAATAATCCTAGACAATTTGGAAAAGCCCTCACAGGTCAATATAAAGGAC
TTTGGCGCTATCGTGTTGGTAATTATCGGGTGATTTGTGACATTGTGGATAATGAAATGATTATCCTTGCTTTGGAAGTT
GGACACAGGAAAGAGATATACAAGCGCTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8641.63 Da
• Isoelectric Point: 3.9607

>AT26193 WP_014407962.1 NC_017040:c1699653-1699426 [Streptococcus pyogenes MGAS15252]
MAMVSLRLNSAEEELFRSYATHTGKTLSELFKTALAQQIEDQLDYETGIQALKRFEENPITYSIDDLIEELENDL

Nucleotide

• Length: 228 bp

>AT26193 NC_017040:c1699653-1699426 [Streptococcus pyogenes MGAS15252]
ATGGCAATGGTATCATTAAGACTGAACAGCGCAGAGGAAGAACTTTTCAGAAGCTACGCTACACACACAGGCAAAACATT
ATCTGAATTATTCAAGACAGCACTAGCACAACAAATTGAAGATCAATTGGACTATGAAACAGGTATTCAAGCTTTAAAAC
GCTTTGAAGAAAATCCCATAACTTATTCTATCGATGATTTAATTGAGGAGTTGGAAAATGACTTATAA

Structures

Toxin

• AlphaFold DB: A0A660A202

Antitoxin

• AlphaFold DB: A0A660A1J7