Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_26(antitoxin)
Location 2325215..2325913 Replicon chromosome
Accession NZ_CP109611
Organism Enterococcus faecalis strain AFL-109F

Toxin (Protein)


Gene name IrrE Uniprot ID -
Locus tag OGM83_RS11350 Protein ID WP_010827745.1
Coordinates 2325569..2325913 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag OGM83_RS11345 Protein ID WP_023895324.1
Coordinates 2325215..2325550 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OGM83_RS11295 (2320341) 2320341..2321096 - 756 WP_142431263.1 DnaD domain protein -
OGM83_RS11300 (2321111) 2321111..2321926 - 816 WP_161972134.1 PD-(D/E)XK nuclease-like domain-containing protein -
OGM83_RS11305 (2321889) 2321889..2322860 - 972 WP_104878921.1 RecT family recombinase -
OGM83_RS11310 (2322910) 2322910..2323230 + 321 WP_010707143.1 hypothetical protein -
OGM83_RS11315 (2323249) 2323249..2323554 - 306 WP_002395805.1 hypothetical protein -
OGM83_RS11320 (2323657) 2323657..2323881 - 225 WP_002367281.1 hypothetical protein -
OGM83_RS11325 (2323878) 2323878..2324177 - 300 WP_010706856.1 hypothetical protein -
OGM83_RS11330 (2324244) 2324244..2324423 - 180 WP_010829956.1 hypothetical protein -
OGM83_RS11335 (2324458) 2324458..2324727 - 270 WP_002365131.1 hypothetical protein -
OGM83_RS11340 (2324740) 2324740..2324922 - 183 WP_002358110.1 hypothetical protein -
OGM83_RS11345 (2325215) 2325215..2325550 + 336 WP_023895324.1 helix-turn-helix transcriptional regulator Antitoxin
OGM83_RS11350 (2325569) 2325569..2325913 + 345 WP_010827745.1 ImmA/IrrE family metallo-endopeptidase Toxin
OGM83_RS11355 (2325971) 2325971..2326699 + 729 WP_002385631.1 potassium channel family protein -
OGM83_RS11360 (2326854) 2326854..2328035 + 1182 WP_271232261.1 site-specific integrase -
OGM83_RS11365 (2328138) 2328138..2328287 - 150 WP_002356321.1 50S ribosomal protein L33 -
OGM83_RS11370 (2328413) 2328413..2330548 - 2136 WP_002359399.1 penicillin-binding protein 2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2286077..2328035 41958


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(21-86)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-60)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13580.58 Da        Isoelectric Point: 5.6177

>T261925 WP_010827745.1 NZ_CP109611:2325569-2325913 [Enterococcus faecalis]
MKSIKELVEEYNVELVFTTLNKRACFDPTYGIIFVNQNLTPSEQEEAIYHELKHVKDHVDIMALYKIPVFRSKMEAEAEQ
YMFRSLIEKYEGQYNYSNVIAHYNLKMGQEVYLK

Download         Length: 345 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12843.45 Da        Isoelectric Point: 4.8252

>AT261925 WP_023895324.1 NZ_CP109611:2325215-2325550 [Enterococcus faecalis]
MTVFDRIKLLAKERGKSLNRIEEELGLPKNVLYRMKTSDNPTKDRLETLANYFDVSVDYLLGRTDNTKATDEKKSDDLDD
VLDNVMSFDGEPLDDHDREVIRAYLKGRFGK

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References