Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1488395..1489007 Replicon chromosome
Accession NC_017040
Organism Streptococcus pyogenes MGAS15252

Toxin (Protein)


Gene name parE Uniprot ID A0A0H3C0F8
Locus tag MGAS15252_RS07230 Protein ID WP_009880846.1
Coordinates 1488672..1489007 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag MGAS15252_RS07225 Protein ID WP_002988079.1
Coordinates 1488395..1488682 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MGAS15252_RS07200 1483575..1484558 - 984 WP_014407847.1 tagatose-bisphosphate aldolase -
MGAS15252_RS07205 1484562..1485491 - 930 WP_014407848.1 tagatose-6-phosphate kinase -
MGAS15252_RS07210 1485537..1486052 - 516 WP_014407849.1 galactose-6-phosphate isomerase subunit LacB -
MGAS15252_RS07215 1486087..1486515 - 429 WP_014407850.1 galactose-6-phosphate isomerase subunit LacA -
MGAS15252_RS07220 1486961..1487734 + 774 WP_011285171.1 DeoR/GlpR family DNA-binding transcription regulator -
MGAS15252_RS07225 1488395..1488682 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
MGAS15252_RS07230 1488672..1489007 + 336 WP_009880846.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MGAS15252_RS09095 1489159..1489629 + 471 Protein_1362 integrase -
MGAS15252_RS09100 1489991..1490140 + 150 WP_011285175.1 integrase -
MGAS15252_RS07240 1490272..1490664 - 393 WP_002982716.1 30S ribosomal protein S9 -
MGAS15252_RS07245 1490685..1491131 - 447 WP_002982710.1 50S ribosomal protein L13 -
MGAS15252_RS07250 1491349..1491555 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
MGAS15252_RS07255 1491552..1492250 - 699 WP_014407851.1 hypothetical protein -
MGAS15252_RS07260 1492386..1493246 - 861 WP_011529009.1 DegV family protein -
MGAS15252_RS07265 1493343..1493861 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-107)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13204.95 Da        Isoelectric Point: 5.6809

>T26192 WP_009880846.1 NC_017040:1488672-1489007 [Streptococcus pyogenes MGAS15252]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFREVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T26192 NC_017040:1488672-1489007 [Streptococcus pyogenes MGAS15252]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTACTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAAGTTTTCCGAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT26192 WP_002988079.1 NC_017040:1488395-1488682 [Streptococcus pyogenes MGAS15252]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT26192 NC_017040:1488395-1488682 [Streptococcus pyogenes MGAS15252]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3C0F8

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References